5-(4-Chloro-2-methylphenoxymethyl)-4-(4-ethoxyphenyl)-4H-1,2,4-triazole-3-thiol CAS 748793-44-4
| CAS No. | 748793-44-4 |
| Molecular Formula | C18H18ClN3O2S |
| Molecular Weight | 375.87 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-(4-Chloro-2-methylphenoxymethyl)-4-(4-ethoxyphenyl)-4H-1,2,4-triazole-3-thiol.
5-(4-Chloro-2-methylphenoxymethyl)-4-(4-ethoxyphenyl)-4H-1,2,4-triazole-3-thiol (CAS 748793-44-4), molecular formula C18H18ClN3O2S and molecular weight 375.87 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5-(4-Chloro-2-methylphenoxymethyl)-4-(4-ethoxyphenyl)-4H-1,2,4-triazole-3-thiol (C18H18ClN3O2S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 5-(4-Chloro-2-methylphenoxymethyl)-4-(4-ethoxyphenyl)-4H-1,2,4-triazole-3-thiol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H18ClN3O2S |
| Molecular Weight | 375.87 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 1-{[6-Chloro-2-(thiophen-2-yl)imidazo[1,2-a]pyridin-3-yl]methyl}piperidine-4-carboxylic acid (CAS 893612-77-6)
- 4-(3-chloro-4-methylphenyl)-5-[(4-ethoxyphenoxy)methyl]-4H-1,2,4-triazole-3-thiol (CAS 723332-61-4)
- 2-[1-(2-Chloro-acetyl)-piperidin-4-ylmethyl]-6-(4-methoxy-phenyl)-2H-pyridazin-3-one (CAS 1229626-96-3)
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- 2-(1-(3-Chloro-4-morpholinophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-N-methyl-2-oxoacetamide (CAS 860610-29-3)
- (E)-({6-chloro-2-phenylimidazo[1,2-a]pyridin-3-yl}methylidene)[(3-methylphenyl)methoxy]amine 478257-25-9 8P-664S (CAS 478257-25-9)
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Recommended Standards
- 4-(4-((4-Chlorophenyl)sulfonyl)piperazin-1-yl)-1H-indole (CAS 256458-64-7)
- 5-(4-Chlorobenzamido)-4-cyano-N,N-diethyl-3-methylthiophene-2-carboxamide (CAS 419558-74-0)
- 5-(4-Chlorophthalazin-1-yl)-N-isopropyl-2-methylbenzenesulfonamide (CAS 732260-56-9)
- 3-(2-Chlorobenzyl)-6,7-dimethoxy-2-(methylthio)quinazolin-4(3H)-imine (CAS 866049-86-7)
- 2-(4-amino-3-methoxyphenyl)ethan-1-ol (CAS 1596780-05-0)
- 3-(pyridin-4-yl)-4,5-dihydro-1,2,4-oxadiazol-5-one (CAS 102227-52-1)
- 5-Bromo-1H-isochromen-1-one (CAS 245677-36-5)
- 2-Fluoro-1-(3-methoxyphenyl)ethan-1-amine (CAS 1556965-46-8)
- 2-(3-(Aminomethyl)piperidin-1-yl)-1-morpholinoethan-1-one (CAS 1019340-54-5)
- 1,1'-(((3,3'-Dimethyl-[1,1'-biphenyl]-4,4'-diyl)bis(azanylylidene))bis(methanylylidene))bis(naphthalen-2-ol) (CAS 16196-97-7)
- 4-(Dimethyl-1,3-thiazol-5-yl)-n-methylpyrimidin-2-amine (CAS 674333-58-5)
- 4H,5H,6H-Pyrrolo[1,2-b]pyrazole-2,3-dicarboxylic acid (CAS 1823428-33-6)
- Faropenem Impurity 66 (CAS CATO-C4X-128966)
- (β-Asp5)-Delta-Sleep Inducing Peptide (CAS 82602-88-8)
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