Methotrexate (sodium) CAS 7532-09-4
| CAS No. | 7532-09-4 |
| Molecular Formula | C20H22N8O5 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Methotrexate (sodium) (CAS 7532-09-4), molecular formula C20H22N8O5Na and molecular weight 477.44 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, Methotrexate (sodium) (C20H22N8O5Na) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 477.44 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Methotrexate (sodium) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H22N8O5 Na |
| Molecular Weight | 477.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1959 |
| Nitrogen Atoms | 8 |
Related Methotrexate Standards
- Methotrexate Impurity 41 (CAS 101810-76-8)
- Methotrexate Dihydrate (CAS 1212284-68-8)
- Methotrexate Hydrate EP Impurity B (CAS 1217459-90-9)
- Methotrexate Hydrate (CAS 133073-73-1)
- Methotrexate Impurity 11 (CAS 143873-72-7)
- Methotrexate EP Impurity E (CAS 19741-14-1)
- Methotrexate EP Impurity C (CAS 2410-93-7)
- Methotrexate EP Impurity G (CAS 2519848-42-9)
Recommended Standards
- 2-[(3-Chlorophenyl)thio]ethanol (CAS 13457-99-3)
- 4-Ethyl-3-nitro-4H-1,2,4-triazole (CAS 139339-81-4)
- 1-(2,2-Difluoroethyl)-5-(propoxymethyl)-1H-pyrazole (CAS 1856044-84-2)
- 1823188-43-7 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-5-fluoro-3,4-dihydropyrimidin-4-one GS-1063 (CAS 1823188-43-7)
- 3-Methoxyphenyl acetate (CAS 5451-83-2)
- 5-Chloro-1-(3-(trifluoromethyl)phenyl)pentan-1-one (CAS 487058-80-0)
- N1,N1-dimethyl-N2-(5-(trifluoromethyl)pyridin-2-yl)ethane-1,2-diamine hydrochloride (CAS 1311279-47-6)
- N-(2-fluoro-5-methylphenyl)thietan-3-amine (CAS 1864122-79-1)
- tert-Butyl (2-sulfamoylphenyl)carbamate (CAS 1465077-92-2)
- (9-D-Asp) Semaglutide X Sodium salt (CAS CATO-CPTD788617)
Why CATO?
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