Methotrexate Impurity 11 CAS 143873-72-7
| CAS No. | 143873-72-7 |
| Molecular Formula | C19H20N8O5 |
| Molecular Weight | 440.41 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Methotrexate Impurity 11 (CAS 143873-72-7) is a high-purity analytical reference standard with the molecular formula C19H20N8O5 and a molecular weight of 440.41 g/mol.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, Methotrexate Impurity 11 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 440.41 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Methotrexate Impurity 11 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H20N8O5 |
| Molecular Weight | 440.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Nitrogen Atoms | 8 |
Related Methotrexate Standards
- Methotrexate EP Impurity B (CAS 54-62-6)
- Methotrexate Impurity 2 (CAS 80407-56-3)
- Methotrexate EP Impurity F (CAS 51865-79-3)
- Methotrexate Impurity 64 (CAS 52980-66-2)
- Methotrexate (CAS 59-05-2)
- Methotrexate EP Impurity C (CAS 2410-93-7)
- Methotrexate-d3 (CAS 432545-63-6)
- Methotrexate Impurity 69 (CAS CATO-C4X-115469)
Recommended Standards
- Ginkgolide C (CAS 15291-76-6)
- 5-[3-(3,4-Dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-3-(3,4,5-trimethoxyphenyl)-1,2,4-oxadiazole (CAS 1775439-98-9)
- Minocycline Impurity 69 (CAS CATO-C4X-169969)
- 3-(((2,4-Dichlorobenzyl)sulfinyl)methyl)-4-methyl-5-((4-methylbenzyl)thio)-4H-1,2,4-triazole (CAS 344272-10-2)
- Methyl 5-bromo-3-chloro-6-hydroxypicolinate (CAS 1820612-76-7)
- Enopeptin A (CAS 139601-96-0)
- Ethyl 2-cyano-3-(4-fluorophenyl)acrylate (CAS 18861-57-9)
- 5-Chloro-3-(3-fluorophenyl)-1,2-oxazole-4-carbaldehyde (CAS 1188031-85-7)
- Methyl 2-(2-chloroquinolin-5-yl)acetate (CAS 475215-58-8)
- 2-((Cyanomethyl)thio)-N-(p-tolyl)acetamide (CAS 669755-54-8)
- N,N-Didesmethyl Sibutramine-d7 HCl (CAS 1188263-87-7)
- 6-Bromo-2-oxaspiro[3.3]heptane (CAS 1363380-78-2)
- (3S,4S)-3,4-Bis(3-hydroxybenzyl)dihydrofuran-2(3H)-one (CAS 185254-87-9)
- Autocamtide-2-Related Inhibitory Peptide TFA (CAS 167114-91-2（free base）)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com