Losartan Impurity 18 CAS 158365-99-2
| CAS No. | 158365-99-2 |
| Molecular Formula | C7H11ClN2 |
| Molecular Weight | 158.63 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Losartan Impurity 18.
As a process- or degradation-related impurity, Losartan Impurity 18 (CAS 158365-99-2, C7H11ClN2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Losartan Impurity 18 (C7H11ClN2) contains a nitrile group, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 3.0, corresponding to approximately 3 ring(s) or double-bond equivalent(s). With a molecular weight of 158.63 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H11ClN2 |
| Molecular Weight | 158.63 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2002 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Losartan Standards
- Losartan Impurity 23 (CAS 193140-43-1)
- Losartan EP Impurity D (CAS 83857-96-9)
- Losartan Impurity 1 (CAS 79047-41-9)
- Losartan Impurity 59 (CAS 57246-71-6)
- Losartan Impurity 20 (CAS 154709-19-0)
- Losartan Impurity 63 (CAS CATO-C4X-168363)
- Losartan Potassium EP Impurity E (CAS 120568-11-8)
- Losartan EP Impurity B (CAS 160514-13-6)
Recommended Standards
- 66909-34-0 2-Chloro-5-methylpyridine-3-carbonitrile DTXSID00495836 (CAS 66909-34-0)
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- 1-cyclopropyl-7-{3-[(ethylamino)methyl]pyrrolidin-1-yl}-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 6575-11-7 AR-1C2683 (CAS 6575-11-7)
- 2-(2-Chloroallyl)thiophene (CAS 1314915-84-8)
- Aprepitant Impurity 23 (CAS 287930-75-0)
- Dotinurad impurity 111 (CAS CATO-C4X-2494111)
- Olopatadine Impurity 23 (CAS 4174-83-8)
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- 5-(Furan-2-yl)-3-(4-nitrophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole (CAS 4155-82-2)
- 1-(3-Methylbenzoyl)piperidine-4-carboxamide (CAS 418777-87-4)
- 6-(2,5-Difluorophenyl)pyridin-3-ol (CAS 1261937-03-4)
- Methyl 3,4-dihydro-2h-1,4-benzoxazine-2-carboxylate hydrochloride (CAS 90922-33-1)
- 6-Amino-1,5-dimethylpyrimidine-2,4(1H,3H)-dione hydrochloride (CAS 1609259-60-0)
- β-Bag Cell Peptide (Aplysia californica) (CAS 109024-47-7)
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