Irinotecan Impurity 27 CAS 802277-44-7
| CAS No. | 802277-44-7 |
| Molecular Formula | C13H24N2O2 |
| Molecular Weight | 240.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Irinotecan Impurity 27.
Irinotecan Impurity 27 (CAS 802277-44-7) is a certified pharmaceutical impurity reference standard with the molecular formula C13H24N2O2 and a molecular weight of 240.34 g/mol.
Structurally, Irinotecan Impurity 27 (C13H24N2O2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 3.0, corresponding to approximately 3 ring(s) or double-bond equivalent(s). With a molecular weight of 240.34 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H24N2O2 |
| Molecular Weight | 240.34 g/mol |
| Appearance | White to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1986 |
| Nitrogen Atoms | 2 |
Related Irinotecan Standards
- Irinotecan Impurity 1 (CAS 116269-53-5)
- Irinotecan Impurity 14 (CAS 110351-94-5)
- Irinotecan Impurity N1 (CAS 1026078-50-1)
- Irinotecan Impurity 14 (CAS 35364-15-9)
- Irinotecan Impurity 7 (CAS 206182-51-6)
- Irinotecan Impurity 70 (CAS 100286-91-7)
- Irinotecan Impurity 49 (CAS 177611-40-4)
- Irinotecan Impurity 59 (CAS CATO-C4X-166759)
Recommended Standards
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- Ulipristal Impurity 8 (CAS 366-29-0)
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- Methylergometrine Impurity 13 (CAS 569-26-6)
- Difelikefalin Impurity 70 (CAS CATO-C4X-304170)
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- Capmatinib Impurity 3 (CAS CATO-C4X-29853)
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- tert-Butyl ((1-benzhydrylazetidin-3-yl)methyl)carbamate (CAS 91189-19-4)
- 2-(2-(2-(Isopropylamino)-2-oxoethyl)thiazol-4-yl)acetic acid (CAS 927976-84-9)
- 7-Bromo-3-(trifluoromethyl)imidazo[1,2-b][1,2,4]triazine (CAS 425378-67-2)
- Baricitinib Impurity 49 (CAS CATO-C4X-226049)
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