Methotrexate Impurity 32 CAS 82778-08-3
| CAS No. | 82778-08-3 |
| Molecular Formula | C7H7ClN6 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrile group, chlorine substitution, an aromatic ring system, Methotrexate Impurity 32 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 247.08 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Methotrexate Impurity 32 (CAS 82778-08-3) is a certified pharmaceutical impurity reference standard with the molecular formula C7H7ClN6HCl and a molecular weight of 247.08 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Methotrexate Impurity 32 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C7H7ClN6 HCl |
| Molecular Weight | 247.08 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Methotrexate Standards
- Methotrexate Impurity 41 (CAS 101810-76-8)
- Methotrexate Dihydrate (CAS 1212284-68-8)
- Methotrexate Hydrate EP Impurity B (CAS 1217459-90-9)
- Methotrexate Hydrate (CAS 133073-73-1)
- Methotrexate Impurity 11 (CAS 143873-72-7)
- Methotrexate EP Impurity E (CAS 19741-14-1)
- Methotrexate EP Impurity C (CAS 2410-93-7)
- Methotrexate EP Impurity G (CAS 2519848-42-9)
Recommended Standards
- Ticagrelor Impurity 4 (CAS CATO-C4X-10934)
- Teriparatide Impurity 5 (CAS CATO-C4X-21855)
- Almotriptan Impurity 10 (CAS CATO-C4X-153810)
- 1-(3-Aminopropoxy)-4-chloro-2-methylbenzene (CAS 50911-66-5)
- Methyl 4-(4-acetamidophenyl)-3-methyl-4-oxobutanoate (CAS 120757-17-7)
- CAS 263873-69-4 (CAS 263873-69-4)
- 2-Amino-6-(3,4-dimethylphenyl)-4-(4-methoxyphenyl)nicotinonitrile (CAS 91923-45-4)
- (2-EThoxyethyl)amine oxalate (CAS 72821-44-4)
- 4-Chloro-6-fluoroquinazoline (CAS 16499-61-9)
- Semaglutide impurity 251 (CAS CATO-C4X-2226251)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com