Dexamethasone Impurity 01 CAS 83880-70-0
| CAS No. | 83880-70-0 |
| Molecular Formula | C29H33FO8 |
| Molecular Weight | 528.57 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Dexamethasone Impurity 01 (CAS 83880-70-0, C29H33FO8) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C29H33FO8, Dexamethasone Impurity 01 contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 528.57 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C29H33FO8 |
| Molecular Weight | 528.57 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Halogen Content | F-containing |
Related Dexamethasone Standards
- Dexamethasone impurity 78 (CAS 1879-72-7)
- Dexamethasone impurity 80 (CAS CATO-C4X-116580)
- Dexamethasone impurity 81 (CAS CATO-C4X-116581)
- Dexamethasone Impurity 118 (CAS CATO-C4X-1165118)
- Dexamethasone Impurity 119 (CAS CATO-C4X-1165119)
- Dexamethasone Impurity 113 (CAS CATO-C4X-1165113)
- Dexamethasone Decanoate (CAS CATO-C4X-116571)
- Dexamethasone Impurity 84 (CAS CATO-C4X-116584)
Recommended Standards
- Cefditoren Impurity 51 (CAS CATO-C4X-135851)
- Methyl 5-((2-ethoxyphenyl)carbamoyl)-4-methyl-2-(3,4,5-trimethoxybenzamido)thiophene-3-carboxylate (CAS 335408-94-1)
- Dabigatran Impurity 122 (CAS CATO-C4X-1089122)
- Methyl 5-((4-ethoxyphenyl)carbamoyl)-4-methyl-2-(3,4,5-trimethoxybenzamido)thiophene-3-carboxylate (CAS 505096-35-5)
- Vonoprazan Impurity 100 (CAS CATO-C4X-1020100)
- Difelikefalin Impurity 19 (CAS CATO-C4X-304119)
- Chlorpromazine EP Impurity D (CAS 1225-64-5)
- 5-Ethynyl-2-methylpyridin-3-amine (CAS 1211537-42-6)
- Anthracene-9,10-diylbis(methylene) dicarbamimidothioate dihydrochloride (CAS 3063-89-6)
- 3-Diphenylphosphanyl-N-methyl-propan-1-amine (CAS 2305926-84-3)
- 1-(3-(Bromomethyl)phenyl)-1H-imidazole hydrobromide (CAS 1956310-75-0)
- 3,5-Dimethyl-1H-pyrazole-4-carbonitrile (CAS 108161-12-2)
- 1-mercapto-4-methyl[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one (CAS 127570-96-1)
- Liraglutide(10-22)TFA Salt (CAS CATO-C4X-199211)
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