Cetirizine EP Impurity F(2HCl) CAS 83881-54-3
| CAS No. | 83881-54-3 |
| Molecular Formula | C21H26N2O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 390.91 g/mol gives Cetirizine EP Impurity F(2HCl) distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Cetirizine EP Impurity F(2HCl) (CAS 83881-54-3), a pharmacopoeial impurity reference standard (molecular formula C21H26N2O3HCl, MW 390.91 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Cetirizine EP Impurity F(2HCl) is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 390.91 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H26N2O3 2*HCl |
| Molecular Weight | 390.91 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Cetirizine Standards
- Cetirizine EP Impurity B (CAS 1000690-91-4)
- Cetirizine Impurity 10 (CAS 1016-78-0)
- rac Cetirizine N-Oxide (Mixture of Diastereomers) (CAS 1076199-80-8)
- Cetirizine USP Related Compound B (CAS 108983-83-1)
- Cetirizine EP Impurity G (CAS 109806-71-5)
- (R)-Cetirizine-d4 Dihydrochloride (CAS 1133210-23-7)
- Cetirizine Impurity N19 (CAS 113740-61-7)
- rac Cetirizine-d8 N-Oxide (CAS 1216444-13-1)
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- methyl ester; (2S)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoic acid (CAS 24435-45-8)
- (4-phenoxyphenyl)magnesium bromide 21473-02-9 4-Phenoxyphenylmagnesium bromide (CAS 21473-02-9)
- 7G1EAO17NV 19093-20-0 5-Octen-2-one, (5E)- (E)-Oct-5-en-2-one 5-Octen-2-one, (E)- EINECS 242-810-9 UNII-7G1EAO17NV (CAS 19093-20-0)
- Semaglutide Impurity 137 (x TFA Salt) (CAS CATO-C4X-2226137)
Why CATO?
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