Rosuvastatin Impurity 82 CAS 854898-46-7
| CAS No. | 854898-46-7 |
| Molecular Formula | C22H26FN3O5S |
| Molecular Weight | 463.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 463.52 g/mol gives Rosuvastatin Impurity 82 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Rosuvastatin Impurity 82 (CAS 854898-46-7), a pharmacopoeial impurity reference standard (molecular formula C22H26FN3O5S, MW 463.52 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Rosuvastatin Impurity 82 (C22H26FN3O5S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 463.52 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H26FN3O5S |
| Molecular Weight | 463.52 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Rosuvastatin Standards
- Rosuvastatin Impurity 74 (CAS 615263-62-2)
- Rosuvastatin (2S,4S)-Lactone (CAS 1809092-87-2)
- (Z)-Rosuvastatin Lactone (CAS CATO-C4X-1169133)
- Rosuvastatin EP Impurity N (CAS 2290571-51-4)
- Rosuvastatin EP Impurity K (CAS 1422954-12-8)
- Rosuvastatin Impurity 256 (CAS 1422954-13-9)
- Rosuvastatin (2R)-Lactone (CAS CATO-C4X-116941)
- Rosuvastatin EP Impurity D (CAS 503610-43-3)
Recommended Standards
- Rosuvastatin Impurity 81 (CAS 854898-47-8)
- Venlafaxine Impurity 13 (CAS CATO-C4X-143413)
- Spirotetramat-enol-glucoside (CAS 1172614-86-6)
- Rosuvastatin (3R,5R)-Lactone (CAS 1422954-11-7)
- Metoclopramide Impurity 86 (CAS CATO-C4X-141586)
- Febuxostat Impurity 54 (CAS 2375033-35-3)
- Berberine Impurity 4 (CAS CATO-C4X-21994)
- (2-(Methylthio)-5-(trifluoromethoxy)phenyl)boronic acid (CAS 957121-11-8)
- Cenobamate Impurity 42 (CAS CATO-C4X-241642)
- 3-Cyclopentyl-N-(2-((4-(4-fluorophenyl)piperazin-1-yl)sulfonyl)ethyl)propanamide (CAS 897618-52-9)
- (R)-tert-Butyl 2-((R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-methoxy-3-oxopropyl)pyrrolidine-1-carboxylate (CAS 2756662-43-6)
- 2,3-Dichloro-5-fluorobenzenesulfonyl chloride (CAS 1805127-64-3)
- (R)-2-(5-(Trifluoromethyl)-2,3-dihydrobenzofuran-3-yl)acetic acid (CAS 2826409-55-4)
- Semaglutide impurity 247 (CAS CATO-C4X-2226247)
Why CATO?
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