Cabazitaxel Impurity 19 CAS 859498-34-3
| CAS No. | 859498-34-3 |
| Molecular Formula | C22H25NO6 |
| Molecular Weight | 399.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Cabazitaxel Impurity 19 (C22H25NO6) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Cabazitaxel Impurity 19 (CAS 859498-34-3, C22H25NO6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Cabazitaxel Impurity 19 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H25NO6 |
| Molecular Weight | 399.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 1 |
Related Cabazitaxel Standards
- Cabazitaxel Impurity 22 (Mixture of Diastereomers) (CAS CATO-C4X-111523)
- Cabazitaxel Impurity 28 (CAS 949459-78-3)
- Cabazitaxel Impurity N4 (CAS 1262147-55-6)
- Cabazitaxel Impurity N2 (CAS 949459-76-1)
- Cabazitaxel Impurity 34 (CAS CATO-C4X-111534)
- Cabazitaxel Impurity 37 (CAS 131023-37-5)
- Cabazitaxel Impurity 37 (CAS CATO-C4X-111537)
- Cabazitaxel Impurity 1 (CAS 183133-97-3)
Recommended Standards
- Moxifloxacin Impurity 83 (CAS 1829588-19-3)
- Moxifloxacin impurity 79 (CAS 2445515-66-0)
- rac-Colchicine, >98% (CAS 209810-38-8)
- Nintedanib Impurity N4 (CAS 1987887-92-2)
- Lincomycin Sulfoxide Impurity 1 (CAS 22083-92-7(Mixture CAS))
- Selexipag Impurity 17 (CAS 475086-28-3)
- Cinnarizine EP Impurity E (CAS 216581-01-0)
- 6-Chloro-1a,2,3,7b-tetrahydro-1H-cyclopropa[c]quinoline (CAS 1784466-96-1)
- (S)-2-(4-(Piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide 2,2,2-trifluoroacetate (CAS 1613220-16-8)
- (S)-1-(1-(Isoquinolin-5-ylsulfonyl)piperidin-4-yl)ethanamine dihydrochloride (CAS 863638-93-1)
- (4-NItrophenyl)trimethylsilane (CAS 4405-33-8)
- 6-(4-Hydroxyphenyl)nicotinonitrile (CAS 149353-76-4)
- Galactan (CAS 39300-87-3)
- Semaglutide impurity 74 (CAS CATO-C4X-222674)
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