Trametinib impurity 4 CAS CATO-C4X-27824
| CAS No. | CATO-C4X-27824 |
| Molecular Formula | C25H25FIN5O3 |
| Molecular Weight | 589.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Trametinib impurity 4 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Trametinib impurity 4 (CAS CATO-C4X-27824) is a certified pharmaceutical impurity reference standard with the molecular formula C25H25FIN5O3 and a molecular weight of 589.40 g/mol.
Trametinib impurity 4 (C25H25FIN5O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/iodine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C25H25FIN5O3 |
| Molecular Weight | 589.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/I-containing |
| Nitrogen Atoms | 5 |
Related Trametinib Standards
- Trametinib Impurity N5 (CAS 1620017-29-9)
- Trametinib Impurity 12 (CAS 1279693-89-8)
- Trametinib impurity 01 (CAS 871701-87-0)
- Trametinib impurity 5 (CAS CATO-C4X-27825)
- Trametinib impurity 04 (CAS 871700-25-3)
- Trametinib Impurity N11 (CAS 871701-23-4)
- Trametinib (CAS 871700-17-3)
- Trametinib-13C-d3 (CAS 2712126-59-3)
Recommended Standards
- Platinum, [1-[[3-[(2-aminoethyl)amino]propyl]amino]-9,10-anthracenedione]dichloro (CAS 131041-28-6)
- Methyl 2-(4-(2,4-dichlorophenoxy)butanamido)-4-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)thiophene-3-carboxylate (CAS 335409-42-2)
- (E)-(1-{4-[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-amido]phenyl}ethylidene)amino 3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carboxylate (CAS 937604-54-1)
- BTZ2F26-2ThBr (CAS 1476807-53-0)
- Enzalutamide Impurity 42 (CAS CATO-C4X-101642)
- Mometasone Impurity 39 (CAS 2408910-08-5)
- Cabazitaxel Impurity 26 (CAS 144790-01-2)
- Brexpiprazole Impurity 133 (CAS 1268367-99-2)
- 5-Fluorobenzo[b]thiophene-2-carbonyl chloride (CAS 1190198-22-1)
- 2,3-Dichloro-5-iodoaniline (CAS 1803823-49-5)
- 3-(5-Ethylthiophen-2-yl)-3-oxopropanal (CAS 1247528-04-6)
- 5-(6-Methoxypyridin-3-yl)pyrimidine (CAS 475275-80-0)
- Cyclopropyl trifluoromethanesulfonate (CAS 25354-42-1)
- D-Tyr10-Tirzepatide (CAS CATO-CPTD788922)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com