Sertraline EP Impurity D (1S, 4S-Isomer) CAS 871838-58-3
| CAS No. | 871838-58-3 |
| Molecular Formula | C17H18ClN |
| Molecular Weight | 271.78 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Sertraline EP Impurity D (1S, 4S-Isomer) (CAS 871838-58-3), a pharmacopoeial impurity reference standard (molecular formula C17H18ClN, MW 271.78 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution, Sertraline EP Impurity D (1S, 4S-Isomer) is typically pale yellow to yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 271.78 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H18ClN |
| Molecular Weight | 271.78 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Sertraline Standards
- Sertraline - Impurity C (Freebase) (CAS 107538-91-0)
- Sertraline Impurity 45 (CAS CATO-C4X-134445)
- Sertraline Impurity 46 (CAS CATO-C4X-134446)
- Sertraline Impurity 71 (CAS CATO-C4X-134471)
- Sertraline Impurity 75 (CAS CATO-C4X-134475)
- Sertraline Impurity 29 (CAS 36159-73-6)
- Sertraline Impurity 69 (CAS CATO-C4X-134469)
- Sertraline Impurity 66 (CAS CATO-C4X-134466)
Recommended Standards
- Verapamil EP Impurity D (CAS 36770-74-8)
- 4-Deschlorosertraline (CAS CATO-C4X-134413)
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- Blonanserin Impurity 20 (CAS CATO-C4X-111020)
- Tryptophan EP Impurity G (CAS 21704-80-3)
- Flunarizine Impurity 9 (CAS 87179-40-6)
- Ticagrelor impurity 136 (CAS 1932275-13-2)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com