Aprepitant Impurity 29 CAS 874460-46-5
| CAS No. | 874460-46-5 |
| Molecular Formula | C20H19F6NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Aprepitant Impurity 29 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Aprepitant Impurity 29 (CAS 874460-46-5) is a certified pharmaceutical impurity reference standard with the molecular formula C20H19F6NO2HCl and a molecular weight of 455.82 g/mol.
The molecular framework of Aprepitant Impurity 29 (C20H19F6NO2HCl) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C20H19F6NO2 HCl |
| Molecular Weight | 455.82 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Aprepitant Standards
- Aprepitant D4 (CAS 1133387-60-6)
- Aprepitant USP Related Compound A (CAS 1148113-53-4)
- Aprepitant Impurity 2 (CAS 1185502-97-9)
- Aprepitant-13C2,d2 (Major) (CAS 1217676-37-3)
- Aprepitant Impurity 7 (CAS 1242175-34-3)
- Aprepitant Impurity 5 (CAS 1242175-40-1)
- Aprepitant Impurity 33 (CAS 1265177-56-7)
- Aprepitant Impurity 38 (CAS 127852-28-2)
Recommended Standards
- Metronidazole EP Impurity C (CAS 5006-69-9)
- Tepotinib impurity 30 (CAS CATO-C4X-337430)
- Phytomenadione/Vitamin K1 Impurity 131 (CAS CATO-C4X-2207131)
- 4-Ethylpyridine-2-carboxylic Acid HCl (CAS 79415-18-2)
- (3-Amino-6-chloropyrazin-2-yl)methanol (CAS 1823953-57-6)
- 1-(2-Methyl-6-(propylamino)pyridin-3-yl)propan-1-one (CAS 1355195-83-3)
- Proparacaine (CAS 499-67-2)
- 3-Propoxy-1H-pyrazole-5-carboxylic acid (CAS 1344687-51-9)
- 5-Methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline (CAS 56135-34-3)
- Peptide 431 (CAS CATO-CPTD788431)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com