Crizotinib Impurity 70 CAS CATO-C4X-102570
| CAS No. | CATO-C4X-102570 |
| Molecular Formula | C8H8ClFO |
| Molecular Weight | 174.60 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Crizotinib Impurity 70 (CAS CATO-C4X-102570, C8H8ClFO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Crizotinib Impurity 70 (C8H8ClFO) is characterized by a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Crizotinib Impurity 70 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H8ClFO |
| Molecular Weight | 174.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
Related Crizotinib Standards
- Crizotinib impurity 19 (CAS CATO-C4X-102519)
- Crizotinib Impurity 73 (CAS CATO-C4X-102573)
- Crizotinib Impurity 68 (CAS CATO-C4X-102568)
- Crizotinib impurity 22 (CAS 3469-69-0)
- Crizotinib impurity 16 (CAS 877397-65-4)
- Crizotinib Impurity 5 (CAS 330156-50-8)
- Crizotinib Impurity 67 (CAS CATO-C4X-102567)
- Crizotinib Impurity 66 (CAS CATO-C4X-102566)
Recommended Standards
- 5-Chlorothiophene-2,4-dicarbaldehyde (CAS 65762-93-8)
- 2-Chlorobicyclo[2.2.1]heptane-2-carboxylic acid (CAS 101774-57-6)
- 4-Chloro-2-ethoxy-1-fluorobenzene (CAS 289039-34-5)
- 2-Chloro-1-cyclobutyl-butane-1,3-dione (CAS 1020732-21-1)
- Oxacillin Impurity 32 (CAS CATO-C4X-232132)
- Ammoxetine Impurity 16 (CAS CATO-C4X-335716)
- 3-Cyclopentyl-3-(4-(5-oxo-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)propanenitrile (CAS 1289218-88-7)
- 5-ethoxy-1,3-benzothiazol-2-amine (CAS 70066-70-5)
- 5-Chloro-3-methyl-1,2,4-thiadiazole (CAS 21734-85-0)
- 3-((Dimethylamino)methyl)phenol (CAS 60760-04-5)
- 8-(Piperazin-1-yl)naphthalen-2-ol (CAS 189350-02-5)
- 5-Amino-1-benzyl-1H-imidazole-4-carbonitrile (CAS 60598-48-3)
- 3-Bromo-4-ethyl-4H-1,2,4-triazole (CAS 64907-56-8)
- Cholecystokinin Octapeptide (desulfated) (H-2070.0005) (CAS 198483-36-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com