Aprepitant Impurity 15 CAS CATO-C4X-116815
| CAS No. | CATO-C4X-116815 |
| Molecular Formula | C30H29F6N4O6P |
| Molecular Weight | 686.54 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Aprepitant Impurity 15 (CAS CATO-C4X-116815), a pharmacopoeial impurity reference standard (molecular formula C30H29F6N4O6P, MW 686.54 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Aprepitant Impurity 15 (C30H29F6N4O6P) is characterized by a steroid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Aprepitant Impurity 15 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C30H29F6N4O6P |
| Molecular Weight | 686.54 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Aprepitant Standards
- Aprepitant impurity 61 (CAS 889852-02-2)
- Aprepitant Impurity 73 (CAS CATO-C4X-114173)
- Aprepitant Impurity 68 (CAS CATO-C4X-114168)
- Aprepitant impurity 65 (CAS CATO-C4X-114165)
- Aprepitant Impurity 79 (CAS CATO-C4X-114179)
- Aprepitant impurity 47 (CAS 172673-20-0)
- Aprepitant EP Impurity B (CAS 2348441-62-1)
- Aprepitant EP Impurity C (CAS 2348441-63-2)
Recommended Standards
- 1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-5-iodopyrimidine-2,4(1H,3H)-dione (CAS 588691-24-1)
- Dicarboxylate of Chloramphenicol Side Chain Acid Polymer (CAS CATO-C4X-232137)
- (9H-fluoren-9-yl)methyl N-(2-((4-(4-(3-bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1,2,5-oxadiazol-3-yl)amino)ethyl)sulfamoylcarbamate (CAS 1771804-78-4)
- Afoxolaner Impurity 34 (CAS CATO-C4X-313734)
- Quetiapine Impurity 85 (CAS 141691-24-9)
- Venetoclax Impurity 35 (CAS CATO-C4X-249535)
- Salbutamol impurity 166 (CAS 2919946-71-5)
- 2-(3-Nitrophenyl)-1,3-thiazolidine-4-carboxylic acid (CAS 69570-81-6)
- 5-Methyl-2-(tributylstannyl)oxazole (CAS 1571145-57-7)
- Faropenem Impurity 5 (CAS CATO-C4X-12895)
- 2-Methyl-2-(6-methyl-pyridin-3-yloxy)-propionic acid ethyl ester (CAS 605681-86-5)
- Sodium 7-hydroxynaphthalene-1-sulfonate (CAS 832-85-9)
- Fmoc-4-fluoro-α-Me-D-Phe-OH ·DCHA (CAS 1217777-84-8)
- Prolactin-Releasing Peptide (1-31) (human) (CAS 215510-22-8)
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