Cinacalcet Impurity 47 CAS 82258-76-2
| CAS No. | 82258-76-2 |
| Molecular Formula | C10H10ClF3 |
| Molecular Weight | 222.63 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Cinacalcet Impurity 47 (CAS 82258-76-2, C10H10ClF3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to fluorine/chlorine substitution, an aromatic ring system, Cinacalcet Impurity 47 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 222.63 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H10ClF3 |
| Molecular Weight | 222.63 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Halogen Content | F/Cl-containing |
Related Cinacalcet Standards
- Cinacalcet Impurity 7 (CAS 585-50-2)
- Cinacalcet Impurity 33 (CAS 94022-99-8)
- Cinacalcet Impurity 34 (CAS 53473-36-2)
- Cinacalcet Impurity 113 (CAS 67646-72-4)
- Cinacalcet Impurity 38 (CAS 67801-07-4)
- Cinacalcet Impurity 45 (CAS 16642-92-5)
- Cinacalcet Impurity 46 (CAS 2062-25-1)
- Cinacalcet Impurity 3 (CAS 93040-58-5)
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