Betamethasone impurity 52 CAS 97168-90-6
| CAS No. | 97168-90-6 |
| Molecular Formula | C24H31BrO6 |
| Molecular Weight | 495.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Betamethasone impurity 52 (CAS 97168-90-6, C24H31BrO6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Betamethasone impurity 52 (C24H31BrO6) contains a flavonoid core, a hydroxyl group, an ether linkage, bromine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C24H31BrO6 |
| Molecular Weight | 495.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | Br-containing |
Related Betamethasone Standards
- Betamethasone Impurity 43 (CAS 4735-65-3)
- Betamethasone impurity 67 (CAS 13796-49-1)
- Betamethasone Impurity 144 (CAS CATO-C4X-1437144)
- Betamethasone benzoate (CAS 22298-29-9)
- Betamethasone Impurity 80 (CAS 25092-10-8)
- Betamethasone Valerate EP Impurity H (CAS 52619-18-8)
- Betamethasone Succinate (CAS 27297-42-3)
- Betamethasone Dipropionate EP Impurity D (CAS 5514-81-8)
Recommended Standards
- Bromodesonide (CAS CATO-C4X-13013)
- Desonide Bromo Impurity N9 (CAS 39672-77-0)
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- Saxagliptin Impurity 70 (CAS CATO-C4X-104970)
- Spectinomycin EP Impurity D (CAS 935756-69-7)
- Suvorexant Impurity 37 (CAS CATO-C4X-181237)
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