Betamethasone Valerate EP Impurity H CAS 52619-18-8
| CAS No. | 52619-18-8 |
| Molecular Formula | C27H37ClO6 |
| Molecular Weight | 493.03 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Betamethasone Valerate EP Impurity H (CAS 52619-18-8, C27H37ClO6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C27H37ClO6, Betamethasone Valerate EP Impurity H contains a steroid core, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 493.03 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO manufactures Betamethasone Valerate EP Impurity H under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C27H37ClO6 |
| Molecular Weight | 493.03 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
| Halogen Content | Cl-containing |
Related Betamethasone Standards
- Betamethasone Succinate (CAS 27297-42-3)
- Betamethasone Impurity 43 (CAS 4735-65-3)
- Betamethasone impurity 52 (CAS 97168-90-6)
- Betamethasone impurity 67 (CAS 13796-49-1)
- Betamethasone Dipropionate EP Impurity D (CAS 5514-81-8)
- Betamethasone impurity 59 (CAS CATO-C4X-143759)
- Betamethasone Impurity 144 (CAS CATO-C4X-1437144)
- Betamethasone Impurity 76 (CAS 5534-01-0)
Recommended Standards
- 2-((4-(4-Chlorophenyl)-5-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)-N-(2-isopropylphenyl)acetamide (CAS 476484-51-2)
- Loperamide EP Impurity G (CAS 109572-89-6)
- N-1-Ethoxyethyl Losartan Carboxaldehyde (CAS 165276-40-4)
- Loperamide N-Oxide (CAS 217471-03-9)
- Dexamethasone Impurity 84 (CAS CATO-C4X-116584)
- Tofacitinib Impurity 11 (CAS 2227197-38-6)
- Rivaroxaban Impurity 181 (CAS CATO-C4X-1090181)
- Arotinolol Impurity 35 (CAS CATO-C4X-185435)
- (s)-2-((Tert-butoxycarbonyl)amino)-3-(2,3-difluorophenyl)propanoic acid (CAS 266360-64-9)
- 4-Hydroxy-N-(2-methoxyphenyl)-1-methyl-1H-benzo[c][1,2]thiazine-3-carbothioamide 2,2-dioxide (CAS 477860-31-4)
- beta-D-Galactopyranoside, (2S,3R,4E)-2-(dimethylamino)-3-hydroxy-4-octadecen-1-yl (CAS 240491-19-4)
- 1-Cyclopropylbut-3-yn-1-ol (CAS 4480-50-6)
- 3-(2-Chloroethyl)-6,7-dimethoxyquinazoline-2,4(1H,3H)-dione (CAS 110231-26-0)
- Semaglutide impurity 272 (CAS CATO-C4X-2226272)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com