Sorafenib Impurity 57 CAS 99970-10-2
| CAS No. | 99970-10-2 |
| Molecular Formula | C12H9NO3 |
| Molecular Weight | 215.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Sorafenib Impurity 57 (C12H9NO3) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 215.20 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Sorafenib Impurity 57 (CAS 99970-10-2) is a certified pharmaceutical impurity reference standard with the molecular formula C12H9NO3 and a molecular weight of 215.20 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H9NO3 |
| Molecular Weight | 215.20 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Nitrogen Atoms | 1 |
Related Sorafenib Standards
- Sorafenib Impurity 32 (CAS 50528-86-4)
- Sorafenib Impurity 57 (CAS 656-96-2)
- Sorafenib Impurity 21 (CAS CATO-C4X-112421)
- Sorafenib Impurity 37 (CAS CATO-C4X-112437)
- Sorafenib Impurity 10 (CAS 2004659-85-0)
- Sorafenib Impurity 59 (CAS 284462-80-2)
- Sorafenib Impurity 30 (CAS 1012058-77-3)
- Sorafenib Impurity 45 (CAS 46843-47-4)
Recommended Standards
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