Sorafenib Impurity 21 CAS CATO-C4X-112421
| CAS No. | CATO-C4X-112421 |
| Molecular Formula | C14H13NO2 |
| Molecular Weight | 227.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Sorafenib Impurity 21 (CAS CATO-C4X-112421) is a certified pharmaceutical impurity reference standard with the molecular formula C14H13NO2 and a molecular weight of 227.26 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, Sorafenib Impurity 21 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 227.26 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H13NO2 |
| Molecular Weight | 227.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Sorafenib Standards
- Sorafenib Impurity 10 (CAS 2004659-85-0)
- Sorafenib Impurity 59 (CAS 284462-80-2)
- Sorafenib Impurity 30 (CAS 1012058-77-3)
- Sorafenib Impurity 45 (CAS 46843-47-4)
- Sorafenib Impurity 57 (CAS 656-96-2)
- Sorafenib Impurity 32 (CAS 50528-86-4)
- Sorafenib Impurity 12 (CAS 343247-69-8)
- Sorafenib Impurity 15 (CAS CATO-C4X-112415)
Recommended Standards
- Pramipexole Impurity 70 (CAS 1373869-90-9)
- Atorvastatin Impurity 135 (CAS 714963-28-7)
- Tofacitinib Impurity 137 (CAS 7400-06-8)
- Atorvastatin Impurity 53 (CAS 125988-01-4)
- Linezolid Impurity 66 (CAS 224323-52-8)
- Mirogabalin Impurity 190 (CAS CATO-C4X-2924190)
- Trazodone Impurity 85 (CAS CATO-C4X-177285)
- 6-Acetyl-4-formylpicolinonitrile (CAS 1393531-61-7)
- Levetiracetam Impurity 47 (CAS CATO-C4X-106747)
- (E)-N1,N1,N4,N4-tetraallylbut-2-ene-1,4-diamine (CAS 955976-98-4)
- 1-tert-Butyl 3-ethyl trans-4-(trifluoromethyl)pyrrolidine-1,3-dicarboxylate (CAS 1428776-53-7)
- 3-(4-Cyanophenyl)-3-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)propanoic acid (CAS 383148-33-2)
- 4-Chloro-N-[3-(6-dimethylamino-4-trifluoromethyl-pyridin-2-yl)-phenyl]-benzamide (CAS 1311279-66-9)
- Semaglutide impurity 29 (CAS 1188328-22-4)
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