Sorafenib Impurity 32 CAS 50528-86-4
| CAS No. | 50528-86-4 |
| Molecular Formula | C8H3ClF3NO |
| Molecular Weight | 221.56 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Sorafenib Impurity 32 (CAS 50528-86-4), a pharmacopoeial impurity reference standard (molecular formula C8H3ClF3NO, MW 221.56 g/mol) used for the identification and quantification of trace impurities in APIs.
Sorafenib Impurity 32 (C8H3ClF3NO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Sorafenib Impurity 32 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H3ClF3NO |
| Molecular Weight | 221.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1971 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Sorafenib Standards
- Sorafenib Impurity 57 (CAS 656-96-2)
- Sorafenib Impurity 21 (CAS CATO-C4X-112421)
- Sorafenib Impurity 57 (CAS 99970-10-2)
- Sorafenib Impurity 10 (CAS 2004659-85-0)
- Sorafenib Impurity 59 (CAS 284462-80-2)
- Sorafenib Impurity 30 (CAS 1012058-77-3)
- Sorafenib Impurity 45 (CAS 46843-47-4)
- Sorafenib Impurity 12 (CAS 343247-69-8)
Recommended Standards
- Regorafenib Impurity 61 (CAS 327-78-6)
- 7-Chloro-5-(trifluoromethyl)-1H-pyrazolo[4,3-b]pyridine (CAS 100478-05-5)
- Regorafenib Impurity 21 (CAS 88330-63-6)
- 4-Chloro-2-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine (CAS 1060815-85-1)
- Cilnidipine impurity 25 (CAS 2197014-75-6)
- Baloxavir Impurity 45 (CAS 2571566-81-7)
- Capecitabine Impurity 12 (CAS 62211-93-2)
- 2-(1-Benzhydrylazetidin-3-yl)propan-2-ol (CAS 256931-42-7)
- 3,5-Dichlorophenol Acetate (CAS 61925-86-8)
- 3-Morpholinoquinazolin-4(3H)-one (CAS 88614-47-5)
- 2-(Aminomethyl)-3-(difluoromethyl)-5-methoxy-6-(trifluoromethyl)pyridine (CAS 1361798-08-4)
- 1-(5-Bromopyrimidin-2-yl)cyclopropanamine dihydrochloride (CAS 1257638-07-5)
- 2,4,5-Trimethyl-1h-pyrrole-3-carbaldehyde (CAS 288089-52-1)
- Staphylococcus Aureus Protein A (SpA)-Derived Peptide (H-2228.0005) (CAS 144979-26-0)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com