Tofacitinib Impurity 216 CAS CATO-C4X-1079216
| CAS No. | CATO-C4X-1079216 |
| Molecular Formula | C21H28N2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Tofacitinib Impurity 216 (CAS CATO-C4X-1079216), a pharmacopoeial impurity reference standard (molecular formula C21H28N2HCl, MW 344.93 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution, Tofacitinib Impurity 216 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 344.93 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C21H28N2 2*HCl |
| Molecular Weight | 344.93 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Tofacitinib Standards
- Tofacitinib Impurity 180 (CAS 100047-45-8)
- Tofacitinib Impurity 133 (CAS 10132-07-7)
- Tofacitinib Impurity 182 (CAS 1053228-28-6)
- Tofacitinib Impurity 123 DiHCl (CAS 1062580-52-2)
- Tofacitinib Impurity 20 (CAS 1092578-43-2)
- Tofacitinib Impurity 38 (CAS 1092578-45-4)
- Tofacitinib Impurity 1 (CAS 1092578-46-5)
- Tofacitinib Impurity 3 (CAS 1092578-47-6)
Recommended Standards
- Loperamide Impurity 16 (CAS CATO-C4X-178816)
- Rosuvastatin EP Impurity A (Calcium Salt) (CAS 1714147-47-3)
- Terlipressin Impurity 26 X TFA Salt (CAS CATO-C4X-219326)
- 2-(4-Fluorophenyl)-6,6-dimethyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine (CAS 1261118-41-5)
- 4-(Cyclopent-1-en-1-yl)-3,5-dimethylisoxazole (CAS 123371-93-7)
- Estazolam impurity 11 (CAS 29975-18-6)
- (R)-1-(2-fluoro-6-(trifluoromethyl)phenyl)ethan-1-amine (CAS 1241679-88-8)
- 1-[4-(Difluoromethoxy)phenyl]-2-phenylethanone (CAS 83882-61-5)
- 2,5-Dichloro-4-(difluoromethoxy)phenylacetic acid 1806352-35-1 (CAS 1806352-35-1)
- Insulin Detemir (CAS 169148-63-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com