Tofacitinib Impurity 32 CAS CATO-C4X-107932
| CAS No. | CATO-C4X-107932 |
| Molecular Formula | C15H17ClN6O |
| Molecular Weight | 332.79 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Tofacitinib Impurity 32 (CAS CATO-C4X-107932, C15H17ClN6O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Tofacitinib Impurity 32 (C15H17ClN6O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H17ClN6O |
| Molecular Weight | 332.79 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Tofacitinib Standards
- Tofacitinib Impurity 16 (CAS 2328165-36-0)
- Tofacitinib Impurity 47 (CAS CATO-C4X-107947)
- Tofacitinib Impurity 17 (CAS 1675248-19-7)
- Tofacitinib Impurity 73 (CAS CATO-C4X-107973)
- Tofacitinib Impurity 228 (CAS CATO-C4X-1079228)
- Tofacitinib Impurity 37 (CAS 1252883-90-1)
- Tofacitinib Impurity 38 (CAS 1092578-45-4)
- Tofacitinib Impurity 39 (CAS 2459302-80-6)
Recommended Standards
- N4-(4-Chlorophenyl)-N6-(2-methoxyethyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine (CAS 896004-86-7)
- 4-(Benzyloxy)naphthalene-1-sulfonyl chloride (CAS 1048919-47-6)
- 1,2,3-Tribromo-5-fluorobenzene (CAS 576-82-9)
- 2-Chloro-n-{[2-(morpholine-4-sulfonyl)phenyl]methyl}acetamide (CAS 1087791-99-8)
- Lesinurad Impurity 1 (CAS 1533519-98-0)
- Semaglutide impurity 24 (CAS CATO-C4X-222624)
- Naproxen Impurity 9 Sodium Salt (CAS CATO-C4X-17089)
- 2-(3-Methoxy-phenyl)piperazine 2-(3-methoxyphenyl)piperazine 790164-75-9 (CAS 790164-75-9)
- 4-((2-Chloro-5-nitrobenzylidene)amino)-3-(3-methoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione (CAS 613249-38-0)
- 4,4'-(((2-Bromo-1,4-phenylene)bis(oxy))bis(methylene))bis(2,2-dimethyl-1,3-dioxolane) (CAS 1956332-70-9)
- 5,7-Dichloro-N-(2,4-dimethylphenyl)thiazolo[4,5-d]pyrimidine-2-sulfonamide (CAS 1000573-16-9)
- 3-(((5-(Azepane-1-carbonyl)-1,2,4-oxadiazol-3-yl)methyl)thio)propanoic acid (CAS 1119450-94-0)
- 3-Hydroxy-2,3-dimethylbutan-2-yl hydrogen (5-(4-methyl-1H-imidazol-1-yl)thiophen-2-yl)boronate (CAS 2223045-74-5)
- Prolactin-Releasing Peptide (12-31) (human) (CAS 235433-36-0)
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