Canagliflozin Impurity 18 CAS CATO-C4X-112318
| CAS No. | CATO-C4X-112318 |
| Molecular Formula | C18H13F2IS |
| Molecular Weight | 426.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Canagliflozin Impurity 18 is closely related to sulfur-containing functionality, fluorine/iodine substitution, a polycyclic aromatic system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Canagliflozin Impurity 18 (CAS CATO-C4X-112318) is a certified pharmaceutical impurity reference standard with the molecular formula C18H13F2IS and a molecular weight of 426.26 g/mol.
Owing to sulfur-containing functionality, fluorine/iodine substitution, a polycyclic aromatic system, Canagliflozin Impurity 18 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 426.26 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Canagliflozin Impurity 18 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H13F2IS |
| Molecular Weight | 426.26 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/I-containing |
| Sulfur Atoms | 1 |
Related Canagliflozin Standards
- Canagliflozin Impurity 28 (CAS CATO-C4X-112328)
- Canagliflozin Impurity 7 (CAS 842133-16-8)
- Canagliflozin Impurity 10 (CAS 1818268-45-9)
- Canagliflozin Impurity 90 (CAS CATO-C4X-112390)
- Canagliflozin Impurity 58 (CAS CATO-C4X-112358)
- Canagliflozin Impurity 100 (CAS CATO-C4X-1123100)
- Canagliflozin Impurity 101 (CAS CATO-C4X-1123101)
- Canagliflozin Impurity 36 (CAS CATO-C4X-112336)
Recommended Standards
- N-((2S,3R,4R,5S,6R)-2-((6-bromonaphthalen-2-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)acetamide (CAS 212069-27-7)
- Crisaborole Impurity 21 (CAS CATO-C4X-202121)
- MK-4965 (CAS 920035-77-4)
- 4-Chloro-3,5-dibromo-2-iodoanisole (CAS 1160574-51-5)
- Atrasentan Impurity 5 (CAS CATO-C4X-33475)
- Testosterone Propionate EP Impurity D (CAS 977-32-2)
- Azithromycin impurity 22 (CAS CATO-C4X-100322)
- Methyl (E)-non-6-enoate (CAS 40709-04-4)
- (S)-1-(tert-Butoxycarbonyl)-4-(6-(trifluoromethyl)-pyridin-3-yl)piperazine-2-carboxylic acid 1786973-28-1 (CAS 1786973-28-1)
- 1-(But-3-yn-1-yl)-1,4-diazepane (CAS 1016804-83-3)
- 3-Hydroxy-3-phenyl-2-(pyridin-4-yl)isoindolin-1-one (CAS 3532-43-2)
- 2-((2,5-Dichloro-N-phenylphenyl)sulfonamido)-N-(3-(trifluoromethyl)phenyl)acetamide (CAS 339103-16-1)
- 1-Methyl-4-phenylpyridin-1-ium iodide (CAS 36913-39-0)
- Semaglutide impurity 208 (CAS CATO-C4X-2226208)
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