Ezetimibe Impurity 33 CAS 1700622-07-6
| CAS No. | 1700622-07-6 |
| Molecular Formula | C25H24FNO3 |
| Molecular Weight | 405.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Ezetimibe Impurity 33 (C25H24FNO3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies Ezetimibe Impurity 33 (CAS 1700622-07-6), a pharmacopoeial impurity reference standard (molecular formula C25H24FNO3, MW 405.46 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H24FNO3 |
| Molecular Weight | 405.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Ezetimibe Standards
- Ezetimibe ketone (CAS 191330-56-0)
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- Ezetimibe Impurity ((S)-4-Phenyloxazolidin-2-one) Sodium salt (CAS 200067-49-8)
- Ezetimibe (CAS 163222-33-1)
- Ezetimibe meta-Fluorobenzene Isomer (CAS CATO-C4X-1098127)
- Ezetimibe Lactone Impurity 128 (CAS CATO-C4X-1098128)
- Ezetimibe Impurity 17(SCH59566) (CAS 1296129-15-1)
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Recommended Standards
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- Isavuconazole impurity 79 (CAS CATO-C4X-1236179)
- Empagliflozin Impurity 67 (CAS CATO-C4X-106567)
- LCZ-696 Impurity 86 (CAS 1795787-14-2)
- 6-Chloro-2-isopropyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS 2760903-15-7)
- N-(sec-Butyl)-2-methoxy-5-methylbenzenesulfonamide (CAS 870540-53-7)
- 4-Chloro-2-(3-fluorophenyl)-6-methylpyrimidine (CAS 180606-98-8)
- N-((5-bromopyridin-3-yl)methyl)ethanesulfonamide (CAS 1202552-53-1)
- 3-(3-(4-Bromophenyl)-1-phenyl-1H-pyrazol-4-yl)propanoic acid (CAS 108446-80-6)
- 1-chlorobicyclo[1.1.1]pentane (CAS 10555-50-7)
- Semaglutide impurity 206 (CAS CATO-C4X-2226206)
Why CATO?
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