Ezetimibe Impurity 99 CAS CATO-C4X-109899
| CAS No. | CATO-C4X-109899 |
| Molecular Formula | C24H22F2N2O5 |
| Molecular Weight | 456.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Ezetimibe Impurity 99 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Ezetimibe Impurity 99 (CAS CATO-C4X-109899, C24H22F2N2O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Ezetimibe Impurity 99 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 456.44 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C24H22F2N2O5 |
| Molecular Weight | 456.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Ezetimibe Standards
- Ezetimibe Impurity 130 (CAS CATO-C4X-1098130)
- Ezetimibe Impurity 122 (CAS CATO-C4X-1098122)
- Ezetimibe Impurity 49 (CAS 1044664-24-5)
- Ezetimibe Impurity 1 Sodium salt (CAS 1400989-75-4)
- Ezetimibe Impurity S (CAS 190448-46-5)
- Ezetimibe Impurity 117 (CAS CATO-C4X-1098117)
- Ezetimibe Impurity 109 (CAS CATO-C4X-1098109)
- Ezetimibe Impurity 129 (CAS CATO-C4X-1098129)
Recommended Standards
- AminoquinolDISCONTINUED. Please see C609759. (CAS 10023-54-8)
- N-(5-((2-((2-Fluorophenyl)amino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-2-(trifluoromethyl)benzamide (CAS 391869-31-1)
- (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1,3-dioxoisoindolin-2-yl)propanoicacid (CAS 1212405-65-6)
- 4-(2-(2-Methoxyphenyl)-3-(4-nitrophenyl)acrylamido)benzene-1-sulfonyl fluoride (CAS 21970-48-9)
- Levofloxacin Impurity 99 (CAS 902172-11-6)
- Berberine Impurity 16 Chloride (CAS 2363741-22-2)
- Tofacitinib Impurity 221 (CAS CATO-C4X-1079221)
- 3-(1-Hydroxyethyl)-4-methyl-1H-1,2,4-triazole-5(4H)-thione (CAS 149762-19-6)
- 8-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline-3-carbonitrile (CAS 2378308-06-4)
- 2-(3,3-Dimethoxypropanoyl)-N-phenylhydrazine-1-carbothioamide (CAS 243455-07-4)
- N-(6-Methyl-4-oxo-1,4-dihydropyrimidin-2-yl)-N-[3-(trifluoromethyl)phenyl]guanidine (CAS 36108-05-1)
- 2-Cyano-3-(2,5-dimethoxyphenyl)-N-(4-fluorophenyl)propanamide (CAS 1260905-59-6)
- 1,3-Bis(2,6-diethylphenyl)-1H-imidazol-3-ium chloride (CAS 852621-03-5)
- Insulin Degludec Impurity 8 (CAS CATO-C4X-21578)
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