Aprepitant Impurity 4 CAS 172822-29-6
| CAS No. | 172822-29-6 |
| Molecular Formula | C23H21F7N4O3 |
| Molecular Weight | 534.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Aprepitant Impurity 4 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
As a process- or degradation-related impurity, Aprepitant Impurity 4 (CAS 172822-29-6, C23H21F7N4O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Aprepitant Impurity 4 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 534.43 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C23H21F7N4O3 |
| Molecular Weight | 534.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2006 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Aprepitant Standards
- Aprepitant (CAS 170729-80-3)
- Aprepitant USP Related Compound A (CAS 1148113-53-4)
- Aprepitant Impurity 2 (CAS 1185502-97-9)
- Aprepitant Impurity 3 (CAS 172822-28-5)
- Aprepitant Impurity 5 (CAS 1242175-40-1)
- Aprepitant Impurity 6 (CAS 170902-81-5)
- Aprepitant impurity 66 (CAS CATO-C4X-114166)
- Aprepitant Impurity 7 (CAS 1242175-34-3)
Recommended Standards
- Perfluorophenyl (((9H-fluoren-9-yl)methoxy)carbonyl)-D-glutaminate (CAS 200622-33-9)
- Aprepitant Impurity 9 (CAS CATO-C4X-11419)
- 5-[[(2S,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one (CAS 221350-96-5)
- Fmoc-Gln-OPfp (CAS 86061-00-9)
- Thiamine Impurity 33 (CAS 861031-76-7)
- Cefotiam Impurity 43 (CAS CATO-C4X-120443)
- Biotin EP Impurity G Bromide (CAS 33719-11-8)
- (E)-N-[(4-Methylphenyl)methyl]-N'-phenyl(methylsulfanyl)methanimidamide (CAS 400078-35-5)
- Ethyl 1-(2-hydroxyethyl)-2-methyl-1H-benzo[d]imidazole-5-carboxylate (CAS 299927-12-1)
- 2-((2-Nitrophenyl)amino)-2-oxoethyl 2-(methylthio)nicotinate (CAS 380549-66-6)
- 2-Phenoxyethyl 4-methylbenzenesulfonate (CAS 43224-81-3)
- 4-Chloro-3-(difluoromethyl)-5-methoxy-2-methylpyridine (CAS 1807075-60-0)
- Posaconazole Impurity 88 (CAS CATO-C4X-1208188)
- (His32,Leu34)-Neuropeptide Y (32-36) (CAS 168916-68-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com