Aprepitant Impurity 3 CAS 172822-28-5
| CAS No. | 172822-28-5 |
| Molecular Formula | C23H21F7N4O3 |
| Molecular Weight | 534.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 534.43 g/mol gives Aprepitant Impurity 3 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Aprepitant Impurity 3 (CAS 172822-28-5, C23H21F7N4O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Aprepitant Impurity 3 (C23H21F7N4O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Aprepitant Impurity 3 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C23H21F7N4O3 |
| Molecular Weight | 534.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2006 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Aprepitant Standards
- Aprepitant (CAS 170729-80-3)
- Aprepitant USP Related Compound A (CAS 1148113-53-4)
- Aprepitant Impurity 2 (CAS 1185502-97-9)
- Aprepitant Impurity 4 (CAS 172822-29-6)
- Aprepitant Impurity 5 (CAS 1242175-40-1)
- Aprepitant Impurity 6 (CAS 170902-81-5)
- Aprepitant impurity 66 (CAS CATO-C4X-114166)
- Aprepitant Impurity 7 (CAS 1242175-34-3)
Recommended Standards
- Perfluorophenyl (((9H-fluoren-9-yl)methoxy)carbonyl)-D-glutaminate (CAS 200622-33-9)
- 5-[[(2S,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one (CAS 221350-96-5)
- 2-((5-(5-Bromo-2-hydroxyphenyl)-4-(2,4-dimethylphenyl)-4H-1,2,4-triazol-3-yl)thio)-N-(2-cyanophenyl)acetamide (CAS 875006-54-5)
- Aprepitant Impurity 9 (CAS CATO-C4X-11419)
- Raltitrexed Impurity 51 (CAS CATO-C4X-138651)
- Niraparib Impurity 56 (CAS 1090871-88-7)
- N-Nitroso Linagliptin impurity 145 (CAS CATO-C4X-1101145)
- 3-bromo-1-(propan-2-yl)-1H,4H,6H,7H-pyrano[4,3-c]pyrazole (CAS 1784559-85-8)
- bicyclo[1.1.1]pentane-1,3-diol (CAS 1312790-52-5)
- 3-(bromomethyl)benzofuran (CAS 38281-49-1)
- 2-(4-Methoxybenzyl)benzo[d]oxazole (CAS 101554-05-6)
- 2-(Benzylthio)-6-methylpyrimidin-4-amine (CAS 214417-53-5)
- 5-Bromo-3-isopropyl-1-methyl-1h-pyrazole (CAS 1780931-99-8)
- Endo-38a-Pro-Exenatide trifluoroacetate salt (CAS 1678416-95-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com