Sitagliptin Impurity 67 CAS CATO-C4X-114467
| CAS No. | CATO-C4X-114467 |
| Molecular Formula | C6H9ClN4 |
| Molecular Weight | 172.62 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Sitagliptin Impurity 67 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Sitagliptin Impurity 67 (CAS CATO-C4X-114467, C6H9ClN4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C6H9ClN4, Sitagliptin Impurity 67 contains a nitrile group, chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 172.62 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C6H9ClN4 |
| Molecular Weight | 172.62 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Sitagliptin Standards
- Sitagliptin Impurity 80 (CAS 658-93-5)
- Sitagliptin Impurity 79 (CAS 81228-09-3)
- Sitagliptin Impurity 78 (CAS 85068-27-5)
- Sitagliptin Impurity 126 (CAS 1555495-76-5)
- Sitagliptin Impurity 163 (CAS 2945884-76-2)
- Sitagliptin Impurity 107 (CAS 89124-06-1)
- Sitagliptin Impurity 62 (CAS 723286-98-4)
- Sitagliptin Impurity 80 (CAS 220199-85-9)
Recommended Standards
- 6-Chloro-N5-ethylpyrimidine-4,5-diamine (CAS 885500-43-6)
- (Z)-3-Chloro-3-(thiophen-3-yl)acrylaldehyde (CAS 1036271-74-5)
- 6-Chloro-N4-ethylpyrimidine-4,5-diamine (CAS 98140-03-5)
- 1-(1-Chloropropyl)-4-fluorobenzene (CAS 1092300-84-9)
- Regadenoson Impurity 60 (CAS CATO-C4X-198560)
- Chlortetracycline Hydrochloride EP Impurity F (CAS CATO-C4X-233023)
- Tegoprazan impurity 20 (CAS CATO-C4X-229720)
- 3-(2,2,2-Trifluoro-1-hydroxyethyl)benzonitrile (CAS 1226507-37-4)
- Amisulpride Impurity 63 (CAS CATO-C4X-104563)
- (7-Chloro-3,4-dihydronaphthalen-2-yl)boronic acid (CAS 521917-62-4)
- (1S,9S)-tert-Butyl 9-amino-10-oxooctahydro-1H-pyridazino[1,2-a][1,2]diazepine-1-carboxylate (CAS 106860-20-2)
- 1-(Benzyloxy)-2,2,6,6-tetramethylpiperidine (CAS 102261-92-7)
- 1,4-Anhydro-L-threitol (CAS 84709-85-3)
- Semaglutide impurity 259 (CAS CATO-C4X-2226259)
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