Isavuconazole Impurity 134 CAS CATO-C4X-1236134
| CAS No. | CATO-C4X-1236134 |
| Molecular Formula | C34H35BrF2N7O5S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Isavuconazole Impurity 134.
As a process- or degradation-related impurity, Isavuconazole Impurity 134 (CAS CATO-C4X-1236134, C34H35BrF2N7O5SI) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Isavuconazole Impurity 134 (C34H35BrF2N7O5SI) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/bromine/iodine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Isavuconazole Impurity 134 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C34H35BrF2N7O5S I |
| Molecular Weight | 898.56 g/mol |
| Purity | 95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Br/I-containing |
| Nitrogen Atoms | 7 |
| Sulfur Atoms | 1 |
Related Isavuconazole Standards
- Isavuconazole Impurity 221 (CAS 1062201-83-5)
- Isavuconazole HCl (CAS 1121545-23-0)
- Isavuconazole Impurity 24 (CAS 1176988-44-5)
- Isavuconazole Impurity 33 (CAS 1180002-01-0)
- Isavuconazole Impurity 60 (CAS 123-73-9)
- Isavuconazole Impurity 62 (CAS 1286730-05-9)
- Isavuconazole-d4 (CAS 1346598-58-0)
- Isavuconazole Impurity N15 (CAS 1443-80-7)
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