Isavuconazole Impurity 189 CAS CATO-C4X-1236189
| CAS No. | CATO-C4X-1236189 |
| Molecular Formula | C32H29ClF2N7O3S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Isavuconazole Impurity 189 (CAS CATO-C4X-1236189, C32H29ClF2N7O3SCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Isavuconazole Impurity 189 (C32H29ClF2N7O3SCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Isavuconazole Impurity 189 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C32H29ClF2N7O3S Cl |
| Molecular Weight | 700.59 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 20.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 7 |
| Sulfur Atoms | 1 |
Related Isavuconazole Standards
- Isavuconazole Impurity 221 (CAS 1062201-83-5)
- Isavuconazole HCl (CAS 1121545-23-0)
- Isavuconazole Impurity 24 (CAS 1176988-44-5)
- Isavuconazole Impurity 33 (CAS 1180002-01-0)
- Isavuconazole Impurity 60 (CAS 123-73-9)
- Isavuconazole Impurity 62 (CAS 1286730-05-9)
- Isavuconazole-d4 (CAS 1346598-58-0)
- Isavuconazole Impurity N15 (CAS 1443-80-7)
Recommended Standards
- Sunitinib Impurity 83 (CAS CATO-C4X-133383)
- Nintedanib Impurity 65 (CAS 757218-01-2)
- Alprazolam EP Impurity C (CAS 36916-19-5)
- n-(4-Bromo-2-methylphenyl)methanesulfonamide (CAS 330468-71-8)
- Baloxavir Marboxil Impurity 193 (CAS 2591558-80-2)
- 7-fluoro-1,5-naphthyridin-3-ol (CAS 2089651-43-2)
- 4-Bromophenyl trifluoroacetate (CAS 5672-84-4)
- 4-Methyl-4-phenylpiperidine-2-carboxylic acid (CAS 2167982-72-9)
- 7-Hydroxy-3-(4-isopropyl-phenoxy)-chromen-4-one (CAS 433700-41-5)
- Vialox Peptide(Pentapeptide-3) diacetate (CAS 725232-44-0)
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