Bendamustine Impurity 18 CAS CATO-C4X-127118
| CAS No. | CATO-C4X-127118 |
| Molecular Formula | C19H27Cl2N3O3S |
| Molecular Weight | 448.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Bendamustine Impurity 18 (CAS CATO-C4X-127118) is a certified pharmaceutical impurity reference standard with the molecular formula C19H27Cl2N3O3S and a molecular weight of 448.41 g/mol.
Bendamustine Impurity 18 (C19H27Cl2N3O3S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H27Cl2N3O3S |
| Molecular Weight | 448.41 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Bendamustine Standards
- Bendamustine Impurity 31 (CAS CATO-C4X-127131)
- Bendamustine Impurity 19 (CAS CATO-C4X-127119)
- Bendamustine Impurity 20 (CAS CATO-C4X-127120)
- Bendamustine impurity 32 (CAS CATO-C4X-127132)
- Bendamustine USP Related Compound I (CAS 87475-54-5)
- Bendamustine Impurity 14 (CAS CATO-C4X-127114)
- Bendamustine Impurity 15 (CAS CATO-C4X-127115)
- Bendamustine impurity 43 (CAS CATO-C4X-127143)
Recommended Standards
- tert-Butyl ((1S,2S)-2-((2,6-dimethoxyphenyl)selanyl)-2,3-dihydro-1H-inden-1-yl)carbamate (CAS 2088566-91-8)
- Quinacillin (CAS 76788-82-4)
- Tenofovir alafenamide Impurity 16 Free base (CAS CATO-C4X-179769)
- Elzasonan (CAS 361343-19-3)
- Mivacurium Chloride Impurity 12 (CAS 161816-38-2)
- Upadacitinib Impurity 161 (CAS CATO-C4X-2405161)
- Azelastine Impurity 18 (CAS CATO-C4X-139618)
- 6-amino-3-(2-methoxyethyl)-3,4-dihydroquinazolin-4-one (CAS 1157072-57-5)
- Sildenafil Impurity 53 (CAS 2021224-02-0)
- 6-(Benzyloxy)-5-nitro-1H-indazole (CAS 1499162-37-6)
- 4-Dimethylamino-2-methoxybenzaldehyde (CAS 84562-48-1)
- 3-Iodo-5,6-dimethylpyrazin-2-amine (CAS 2089377-42-2)
- 4-Chloro-2-(methylsulfonyl)thiazolo[5,4-c]pyridine (CAS 1398511-49-3)
- Tirzepatide Impurity 34 (CAS CATO-C4X-324034)
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