Sunitinib Impurity 66 CAS CATO-C4X-133366
| CAS No. | CATO-C4X-133366 |
| Molecular Formula | C36H34F2N8O4 |
| Molecular Weight | 680.70 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Sunitinib Impurity 66.
As a process- or degradation-related impurity, Sunitinib Impurity 66 (CAS CATO-C4X-133366, C36H34F2N8O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Sunitinib Impurity 66 (C36H34F2N8O4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C36H34F2N8O4 |
| Molecular Weight | 680.70 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 23.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
Related Sunitinib Standards
- Sunitinib Impurity 90 (CAS CATO-C4X-133390)
- Sunitinib Impurity 77 (CAS CATO-C4X-133377)
- Sunitinib Impurity 79 (CAS CATO-C4X-133379)
- Sunitinib Impurity 70 (CAS CATO-C4X-133370)
- Sunitinib Impurity 59 (CAS CATO-C4X-133359)
- Sunitinib Impurity 64 (CAS CATO-C4X-133364)
- Sunitinib Impurity 2 (CAS 356068-99-0)
- Sunitinib Impurity 74 (CAS CATO-C4X-133374)
Recommended Standards
- (3s,4s,4ar,5r,9br,10s)-4-(3,5-dihydroxyphenyl)-3,5,10-tris(4-hydr Oxyphenyl)-3,4,4a,5,9b,10-hexahydro-11-oxabenzo[5,6]cyclohepta[1, 2,3,4-jkl]-as-indacene-2,6,8-triol 625096-18-6 (CAS 625096-18-6)
- N1,N1,N4,N4-Tetrakis(4-(4H-1,2,4-triazol-4-yl)phenyl)benzene-1,4-diamine (CAS 2244292-47-3)
- Fmoc-Val-Ala-PAB-PNP (CAS 1394238-92-6)
- Mal-amido-PEG10-acid (CAS 2785355-74-8)
- Bevantolol Impurity 19 (CAS CATO-C4X-241119)
- Nimodipine Impurity 10 (CAS CATO-C4X-138510)
- Mecamylamine Impurity 2 (CAS 91369-45-8)
- 3-Methyl-5-(1,2,5,6-tetrahydropyridin-3-yl)-1,2,4-oxadiazole hydrochloride (CAS 129594-87-2)
- 2-Bromo-5-(fluorosulfonyl)benzoic acid (CAS 1422570-52-2)
- Tapentadol O-beta-D-Glucuronide (CAS 1300037-86-8)
- Methyl (1S,2R,4aS,6aS,6bR,8aR,12aR,12bR,14bS)-1,2,6a,6b,9,9,12a-heptamethyl-10-oxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylate (CAS 989-72-0)
- Isoindoline-2-carboximidamide (CAS 23363-01-1)
- 2-Keto-D-Glucose (CAS 1854-25-7)
- Neuropeptide K (human, porcine, rat) trifluoroacetate salt (CAS 96827-05-3)
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