Betamethasone impurity 102 CAS CATO-C4X-1437102
| CAS No. | CATO-C4X-1437102 |
| Molecular Formula | C22H28FO8P |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Betamethasone impurity 102 is closely related to a flavonoid core, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Betamethasone impurity 102 (CAS CATO-C4X-1437102), a pharmacopoeial impurity reference standard (molecular formula C22H28FO8PNa, MW 493.42 g/mol) used for the identification and quantification of trace impurities in APIs.
Betamethasone impurity 102 (C22H28FO8PNa) contains a flavonoid core, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H28FO8P 2*Na |
| Molecular Weight | 493.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
Related Betamethasone Standards
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Recommended Standards
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- Benzyl 3,3-difluoro-2,2-dimethyl-4-oxobutanoate (CAS 2813205-00-2)
- 6-Bromo-1H-benzo[de]quinolin-2(3H)-one (CAS 2767589-82-0)
- 2-(Dimethylamino)-5-iodobenzaldehyde (CAS 1289042-69-8)
- ((2R,3S,4R,5R)-5-(6-(((S)-2,3-dihydro-1h-inden-1-yl)amino)-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl sulfamate (CAS 905578-77-0)
- 1-His-N-a-ethylidene Semaglutide (CAS CATO-C4X-2226252)
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