Timolol EP Impurity E Maleate CAS CATO-C4X-149610
| CAS No. | CATO-C4X-149610 |
| Molecular Formula | C17H26N4O6S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Timolol EP Impurity E Maleate is closely related to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Timolol EP Impurity E Maleate (CAS CATO-C4X-149610, C17H26N4O6SC4H4O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Timolol EP Impurity E Maleate (C17H26N4O6SC4H4O4) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H26N4O6S C4H4O4 |
| Molecular Weight | 530.55 g/mol |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Timolol Standards
- Timolol EP Impurity E (CAS 1026075-53-5)
- Timolol EP Impurity C (CAS 1391068-18-0)
- Timolol EP Impurity B（S-Isomer) (CAS 158636-96-5)
- Timolol EP Impurity H (CAS 158636-97-6)
- r-tImolol 2-butenedioate (CAS 1820576-27-9)
- Timolol Impurity 16 (CAS 214691-24-4)
- Timolol EP Impurity I (CAS 2469037-77-0)
- Timolol (CAS 26839-75-8)
Recommended Standards
- Oxazepam impurity 12 (CAS 13788-59-5)
- Acetaminophen Impurity 38 (CAS CATO-C4X-121138)
- Diphenhydramine impurity 9 (CAS CATO-C4X-14249)
- Z-Asp(OMe)-OH (CAS 3160-47-2)
- 2-(2,2-dimethyloxetan-3-yl)acetonitrile (CAS 114042-00-1)
- 2'-(2,2,2-Trifluoroethoxy)acetophenone (CAS 1017050-36-0)
- Methyl 5-Bromo-1,2,4-triazole-3-carboxylate (CAS 704911-47-7)
- 2-(1-(2-Fluorophenyl)-1H-pyrazol-5-yl)pyridine (CAS 1269291-78-2)
- Tyrphostin B46, >98% (CAS 133550-34-2)
- Semaglutide Impurity 131 (CAS 2618647-80-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com