Midazolam Impurity 27 CAS CATO-C4X-150927
| CAS No. | CATO-C4X-150927 |
| Molecular Formula | C16H15ClFN3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Midazolam Impurity 27 (C16H15ClFN3C4H4O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Midazolam Impurity 27 (CAS CATO-C4X-150927) is a certified pharmaceutical impurity reference standard with the molecular formula C16H15ClFN3C4H4O4 and a molecular weight of 419.84 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Midazolam Impurity 27 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H15ClFN3 2*C4H4O4 |
| Molecular Weight | 419.84 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Midazolam Standards
- Midazolam N-β-D-Glucuronide (~90%, contains ~10% inorganic salts) (CAS 1033824-50-8)
- Midazolam EP Impurity I (CAS 112811-67-3)
- Midazolam EP Impurity H (CAS 119401-13-7)
- Midazolam 2,5-Dioxide-d6 (CAS 1215321-98-4)
- MidazolaM-d6 (CAS 1246819-79-3)
- Midazolam Impurity 20 (CAS 151921-06-1)
- Midazolam Impurity 14 (CAS 2531288-23-8)
- Midazolam EP Impurity F (CAS 2886-65-9)
Recommended Standards
- Everolimus Impurity 23 (CAS CATO-C4X-112223)
- Pramipexole Impurity 57 (CAS CATO-C4X-110757)
- Fluticasone Impurity 25 (CAS 1374153-88-4)
- 5-Methyl-1H-indazole-3-carbohydrazide (CAS 1203-96-9)
- Paclitaxel Impurity 53 (CAS CATO-C4X-184253)
- Tafluprost Impurity 4 (CAS CATO-C4X-21634)
- 2-Nitro-4-(trifluoromethyl)benzaldehyde (CAS 109466-87-7)
- 3-(2-(4-Chlorophenyl)imidazo[1,2-a]pyridin-3-yl)acrylic acid (CAS 817172-46-6)
- 3-fluoro-5-(trifluoromethyl)benzene-1-sulfonyl chloride (CAS 886499-99-6)
- Tirzepatide Impurity 17 (CAS CATO-C4X-324017)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com