Paclitaxel Impurity 53 CAS CATO-C4X-184253
| CAS No. | CATO-C4X-184253 |
| Molecular Formula | C61H71NO15Si |
| Molecular Weight | 1086.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Paclitaxel Impurity 53 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Paclitaxel Impurity 53 (CAS CATO-C4X-184253) is a certified pharmaceutical impurity reference standard with the molecular formula C61H71NO15Si and a molecular weight of 1086.30 g/mol.
Structurally, Paclitaxel Impurity 53 (C61H71NO15Si) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 27.0, corresponding to approximately 27 ring(s) or double-bond equivalent(s). With a molecular weight of 1086.30 g/mol, it falls into the high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C61H71NO15Si |
| Molecular Weight | 1086.30 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 27.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Paclitaxel Standards
- Paclitaxel EP Impurity I (CAS 2157462-42-3)
- DHA-Paclitaxel (CAS 199796-52-6)
- Paclitaxel Ceribate (CAS 186040-50-6)
- Paclitaxel EP Impurity K (CAS 148930-55-6)
- Paclitaxel EP Impurity J (CAS 2757197-26-3)
- Paclitaxel EP Impurity L (CAS 92950-39-5)
- Paclitaxel Impurity 57 (CAS 1053697-17-8)
- Paclitaxel EP Impurity O (CAS 219783-77-4)
Recommended Standards
- Amphotericin B Impurity 29 (CAS CATO-C4X-184429)
- (d(CH2)51,D-Ile2,Ile4,Arg8,Ala-NH29)-Vasopressin (CAS 114455-29-7)
- H-Arg-Lys-Gly-Asp-Ile-Lys-Ser-Tyr-pNA (L-2110.0001) (CAS 204450-29-3)
- N-((2S,5S,8S,11S,14S,17S,20S)-1,24-Diamino-17-(4-aminobutyl)-2-benzyl-11-(3-guanidinopropyl)-14-(hydroxymethyl)-5-isobutyl-8-methyl-1,4,7,10,13,16,19-heptaoxo-3,6,9,12,15,18-hexaazatetracosan-20-yl)palmitamide (CAS 371131-16-7)
- Oclacitinib Impurity 38 (CAS CATO-C4X-301838)
- Lidocaine impurity 58 (CAS CATO-C4X-167958)
- Allopurinol impurity 16 (CAS CATO-C4X-145816)
- 6-BROMO-7-METHYLCHROMAN-4-AMINE (CAS 1273604-84-4)
- 1-Ethyl-1H-benzo[d]imidazole-4,7-diol (CAS 705927-83-9)
- 3-Ethoxy-1,2-propanediol (CAS 1874-62-0)
- (R)-1-(2-chloro-6-(trifluoromethyl)phenyl)ethan-1-amine (CAS 1703844-26-1)
- Nε-(Ethoxycarbonylmethyl)-L-lysine-d4 Methyl Ester (CAS 1331910-52-1)
- Tert-butyl 6-fluoro-3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole-1-carboxylate (CAS 1333222-21-1)
- Semaglutide impurity 208 (CAS CATO-C4X-2226208)
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