Midazolam Impurity 33 CAS CATO-C4X-150933
| CAS No. | CATO-C4X-150933 |
| Molecular Formula | C18H14ClFN2O2 |
| Molecular Weight | 344.77 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Midazolam Impurity 33 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Midazolam Impurity 33 (CAS CATO-C4X-150933) is a certified pharmaceutical impurity reference standard with the molecular formula C18H14ClFN2O2 and a molecular weight of 344.77 g/mol.
Midazolam Impurity 33 (C18H14ClFN2O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Midazolam Impurity 33 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H14ClFN2O2 |
| Molecular Weight | 344.77 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Midazolam Standards
- Midazolam Impurity 32 (CAS CATO-C4X-150932)
- Midazolam Impurity 1 (CAS 59468-90-5)
- Midazolam EP Impurity D (CAS 59468-83-6)
- Midazolam Impurity 41 (CAS 59468-85-8)
- Midazolam EP Impurity I (CAS 112811-67-3)
- Midazolam Impurity 13 (CAS CATO-C4X-150913)
- Midazolam Impurity 25 (CAS CATO-C4X-150925)
- Midazolam 2-Oxide (CAS 59468-86-9)
Recommended Standards
- N-(3-Chloro-2-methylphenyl)-1-(4-fluorophenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide (CAS 899357-78-9)
- Sulfadoxine impurity 7 (CAS CATO-C4X-27917)
- 3-[(2-Chloro-6-fluorophenyl)methyl]-4-hydroxy-1-[(pyridin-4-yl)methyl]-1,2-dihydropyridin-2-one (CAS 477860-55-2)
- 6-(2-Chlorophenyl)-2-(methylthio)pyrimido[5,4-e][1,2,4]triazolo[4,3-a]pyrimidin-5(6H)-one (CAS 1395026-89-7)
- Lapatinib Impurity 11 (CAS 231278-83-4)
- Tirofiban Impurity 44 (CAS CATO-C4X-125444)
- Tolperisone Impurity 6 (CAS 158176-60-4)
- Methyl 4,6-O-benzylidene-2,3-di-O-methanesulfonyl-a-D-glucopyranoside (CAS 6619-12-1)
- 7-Bromo-2-iodo-1-(phenylsulfonyl)-1H-indole (CAS 2514953-08-1)
- A,a,1-trimethyl-1h-imidazole-2-acetic acid (CAS 865157-15-9)
- 4-(2-Chlorophenyl)-5-methylthiazol-2-ylamine (CAS 206555-30-8)
- 1-Bromo-2-isobutoxynaphthalene (CAS 1309933-75-2)
- 1-(4-(Ethylsulfonyl)-2-fluorophenyl)-3-methylpiperazine (CAS 1000339-75-2)
- Semaglutide impurity 34 (CAS CATO-C4X-222634)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com