Methylnaltrexone Bromide Impurity 8 CAS CATO-C4X-15218
| CAS No. | CATO-C4X-15218 |
| Molecular Formula | C23H28NO5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Methylnaltrexone Bromide Impurity 8 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Methylnaltrexone Bromide Impurity 8 (CAS CATO-C4X-15218) is a certified pharmaceutical impurity reference standard with the molecular formula C23H28NO5Br and a molecular weight of 478.38 g/mol.
Based on its molecular formula C23H28NO5Br, Methylnaltrexone Bromide Impurity 8 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 478.38 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H28NO5 Br |
| Molecular Weight | 478.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Methylnaltrexone Standards
- Methylnaltrexone Bromide Impurity 4 (CAS 1005410-32-1)
- Methylnaltrexone Bromide Impurity 1 (CAS 1027638-96-5)
- Methylnaltrexone Bromide - API Standards (CAS 916055-92-0)
- Methylnaltrexone (CAS 916055-93-1)
- Methylnaltrexone Bromide Impurity 25 (CAS CATO-C4X-147525)
- Methylnaltrexone Bromide Impurity 10 (CAS CATO-C4X-152110)
- Methylnaltrexone Bromide Impurity 11 (CAS CATO-C4X-152111)
- Methylnaltrexone Bromide Impurity 12 (CAS CATO-C4X-152112)
Recommended Standards
- Ciprofloxacin impurity 43 (CAS 105093-21-8)
- Donepezil Impurity 58 (CAS 130927-68-3)
- Famotidine impurity 68 (CAS 83700-77-0)
- Ziprasidone impurity 50 (CAS 128396-56-5)
- 1-Methyl-N-(4-methylbenzyl)pyrrolidin-3-amine (CAS 1250891-31-6)
- 2-cyclopropylcyclohexane-1-carboxylic acid (CAS 1512893-46-7)
- 2-Cyclopentyl-N-methylethan-1-amine hydrochloride (CAS 854413-64-2)
- 2-(2-MEthylphenoxy)phenol (CAS 26321-31-3)
- 1,9-Nonanediol (CAS 3937-56-2)
- D-Ser39-Tirzepatide (CAS CATO-CPTD788679)
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