Dolutegravir Impurity 65 CAS CATO-C4X-162065
| CAS No. | CATO-C4X-162065 |
| Molecular Formula | C18H15F2N3O6 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 796.64 g/mol gives Dolutegravir Impurity 65 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Dolutegravir Impurity 65 (CAS CATO-C4X-162065) is a certified pharmaceutical impurity reference standard with the molecular formula C18H15F2N3O6C18H13F2N3O5 and a molecular weight of 796.64 g/mol.
Structurally, Dolutegravir Impurity 65 (C18H15F2N3O6C18H13F2N3O5) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 24.0, corresponding to approximately 24 ring(s) or double-bond equivalent(s). With a molecular weight of 796.64 g/mol, it falls into the high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Dolutegravir Impurity 65 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H15F2N3O6 C18H13F2N3O5 |
| Molecular Weight | 796.64 g/mol |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 24.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 6 |
Related Dolutegravir Standards
- Dolutegravir (CAS 1051375-16-6)
- Dolutegravir Sodium Salt (CAS 1051375-19-9)
- Dolutegravir Impurity 22 (CAS 1206102-11-5)
- Dolutegravir Sodium Monohydrate - API Standards (CAS 1229006-39-6)
- Dolutegravir Impurity N13 (CAS 1246616-73-8)
- Dolutegravir Impurity 14 (CAS 127958-23-0)
- Dolutegravir Impurity 2 (CAS 1309560-49-3)
- Dolutegravir Impurity 27 (CAS 1335210-31-5)
Recommended Standards
- Ertapenem Impurity 16 (CAS 266337-30-8)
- Mirabegron Impurity 10 (CAS 1684452-81-0)
- Difelikefalin Impurity 27 (CAS 123442-34-2)
- Tert-butyl 7-bromo-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate (CAS 1779125-91-5)
- Galβ(1-3)[GlcNAcβ(1-6)]GalNAc (CAS 73499-58-8)
- Oxaliplatin EP Impurity C (CAS 111321-67-6)
- 4-(n-(4-((Difluoromethyl)thio)phenyl)sulfamoyl)benzoic acid (CAS 327092-87-5)
- 4-Ethoxy-1,1,1-trifluoro-4-(4-methyl-piperazin-1-yl)-but-3-en-2-one (CAS 1365994-88-2)
- 3-(M-tolyloxy)propanal (CAS 92016-60-9)
- Semaglutide impurity 72 (CAS CATO-C4X-222672)
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