Fluticasone Impurity 67 CAS CATO-C4X-165067
| CAS No. | CATO-C4X-165067 |
| Molecular Formula | C22H28F2O5 |
| Molecular Weight | 410.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Fluticasone Impurity 67 (CAS CATO-C4X-165067), a pharmacopoeial impurity reference standard (molecular formula C22H28F2O5, MW 410.45 g/mol) used for the identification and quantification of trace impurities in APIs.
Fluticasone Impurity 67 (C22H28F2O5) contains a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H28F2O5 |
| Molecular Weight | 410.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
Related Fluticasone Standards
- Fluticasone Impurity 56 (CAS 28416-84-4)
- Fluticasone Impurity 57 (CAS CATO-C4X-165057)
- Fluticasone Impurity 58 (CAS CATO-C4X-165058)
- Fluticasone Impurity 61 (CAS CATO-C4X-165061)
- Fluticasone Impurity 63 (CAS CATO-C4X-165063)
- Fluticasone Impurity 45 (CAS 80473-92-3)
- Fluticasone Propionate USP Related Compound J (CAS 28416-82-2)
- Fluticasone Impurity 60 (CAS CATO-C4X-165060)
Recommended Standards
- Flumethasone Impurity 1 (CAS 60895-22-9)
- Flumetasone Impurity 15 (CAS CATO-C4X-191015)
- Flumethasone Methyl (CAS CATO-C4X-19106)
- tert-butyl-[(1S)-1-(2-iodoethyl)-3-phenyl-propoxy]-dimethyl-silane (CAS 876953-73-0)
- Vortioxetine Impurity 60 (CAS 1049755-55-6)
- Alectinib Impurity 76 (CAS CATO-C4X-283676)
- Enzalutamide Impurity 5 (CAS 179232-29-2)
- N-Methyl-DL-tyrosine hydrochloride (CAS 19897-63-3)
- (6-(Dimethylamino)pyridin-3-yl)methanol hydrochloride (CAS 1269054-79-6)
- n-(4-Bromo-2-fluorophenyl)-2-(tert-butylamino)acetamide (CAS 923224-66-2)
- Lefamulinum Impurity 44 (CAS CATO-C4X-304744)
- 3,5-Dimethyl-2-(4-methylpiperazinomethyl) benzophenone (CAS 898783-23-8)
- 5,7-Dichlorobenzo[d]isoxazol-3(2H)-one (CAS 66571-27-5)
- Acetyl-(Leu28ยท31)-Neuropeptide Y (24-36) (CAS 155709-24-3)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com