Riociguat Impurity 44 CAS CATO-C4X-174944
| CAS No. | CATO-C4X-174944 |
| Molecular Formula | C14H12FN5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Riociguat Impurity 44 is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Riociguat Impurity 44 (CAS CATO-C4X-174944, C14H12FN5HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C14H12FN5HCl, Riociguat Impurity 44 contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 305.74 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Riociguat Impurity 44 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H12FN5 HCl |
| Molecular Weight | 305.74 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Riociguat Standards
- Riociguat-13C-d3 (CAS 1304478-43-0)
- Riociguat Impurity 2 (CAS 1361569-10-9)
- Riociguat Impurity 16 (CAS 1361569-18-7)
- Riociguat Impurity 18 (CAS 1361569-23-4)
- Riociguat Impurity 1 (CAS 1702271-98-4)
- Riociguat Impurity N10 (CAS 2101651-50-5)
- Riociguat Impurity N3 (CAS 2512205-25-1)
- Riociguat Impurity 30 (CAS 2518331-19-4)
Recommended Standards
- Luliconazole Impurity 1 (CAS 126534-31-4)
- Brexpiprazole impurity 114 (CAS 131540-81-3)
- Dalbavancin Impurity 33 (CAS CATO-C4X-160233)
- 3-(4-chlorophenyl)cyclohexan-1-one (CAS 136333-71-6)
- 100234-62-6 9H-Pyrido[3,4-b]indol-8-ol,1-ethyl-4-methoxy- (CAS 100234-62-6)
- 1-Bromo-2-propoxynaphthalene (CAS 60514-36-5)
- (S)-1-(3-((S)-2-CARBOXYPYRROLIDIN-1-YL)PROPYL)PYRROLIDINE-2-CARBOXYLIC ACID (CAS 1263078-15-4)
- Methyl 4-(chloro(hydroxyimino)methyl)benzoate (CAS 101023-70-5)
- 5-(Chloromethyl)-6-(difluoromethyl)-3-fluoropyridin-2-amine (CAS 1804951-50-5)
- Biotinyl-S6 Phosphate Acceptor Peptide trifluoroacetate salt (CAS 1815618-12-2)
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