Trimetazidine Impurity 1 CAS CATO-C4X-18031
| CAS No. | CATO-C4X-18031 |
| Molecular Formula | C14H22N2O4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Trimetazidine Impurity 1.
As a process- or degradation-related impurity, Trimetazidine Impurity 1 (CAS CATO-C4X-18031, C14H22N2O4HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Trimetazidine Impurity 1 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 318.80 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Trimetazidine Impurity 1 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H22N2O4 HCl |
| Molecular Weight | 318.80 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Trimetazidine Standards
- Trimetazidine EP Impurity A DiHCl (CAS 107049-57-0)
- Trimetazidine EP Impurity G (CAS 110-85-0)
- Trimetazidine Impurity 5 (CAS 1133-49-9)
- Trimetazidine EP Impurity F（Dihydrochloride） (CAS 113698-83-2)
- Trimetazidine-D8 Dihydrochloride (CAS 1219795-37-5)
- Trimetazidine-d8 Dihydrochloride (CAS 1219908-67-4)
- Trimetazidine EP Impurity B (CAS 1257-19-8)
- Trimetazidine Dihydrochloride (CAS 13171-25-0)
Recommended Standards
- Flurbiprofen impurity 120 (CAS 87657-78-1)
- Edoxaban N-Oxide Monomer Impurity 1 (CAS 1974272-82-6)
- Bisoprolol Impurity 52 (CAS 293302-44-0)
- 2-[(4-Bromophenyl)sulfanyl]-3-[3-(trifluoromethyl)phenyl]quinoline (CAS 339103-53-6)
- 1,1-difluoro-N-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]methanesulfonamide hydrochloride (CAS 1797883-28-3)
- 2-(2-Fluorophenoxy)-1-(piperazin-1-yl)propan-1-one (CAS 1016806-02-2)
- Atogepant Impurity 64 (CAS CATO-C4X-328564)
- N-(9-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide (CAS 333335-93-6)
- Piperazine Impurity 17 (CAS CATO-C4X-242717)
- Des-Trp25-Tirzepatide (CAS CATO-CPTD788948)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com