Nintedanib Impurity 146 CAS CATO-C4X-1814146
| CAS No. | CATO-C4X-1814146 |
| Molecular Formula | C10H10Cl4O3 |
| Molecular Weight | 320.00 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Nintedanib Impurity 146.
As a process- or degradation-related impurity, Nintedanib Impurity 146 (CAS CATO-C4X-1814146, C10H10Cl4O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, Nintedanib Impurity 146 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 320.00 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H10Cl4O3 |
| Molecular Weight | 320.00 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Nintedanib Standards
- Nintedanib Impurity 147 (CAS CATO-C4X-1814147)
- Nintedanib Impurity 149 (CAS CATO-C4X-1814149)
- Nintedanib Impurity 129 (CAS CATO-C4X-1814129)
- Nintedanib Impurity 85 (CAS CATO-C4X-181485)
- Nintedanib Impurity 122 (CAS CATO-C4X-1814122)
- Nintedanib Impurity 89 (CAS CATO-C4X-181489)
- Nintedanib Impurity 154 (CAS CATO-C4X-1814154)
- Nintedanib Impurity 158 (CAS 1023942-14-4)
Recommended Standards
- Bis(3,5-dichlorophenyl)methanone (CAS 92758-86-6)
- Bis(3,4-dichlorophenyl)methanone (CAS 75795-07-2)
- 3,3,4,5-Tetrachlorobenzophenone (CAS 844885-32-1)
- 3,3′,4,4′-Tetrachloroazobenzene (CAS 14047-09-7)
- Baclofen Impurity 65 (CAS CATO-C4X-101265)
- Fluconazole Impurity 48 (CAS 1222655-38-0)
- Baloxavir Marboxil Impurity 157 (CAS CATO-C4X-2108157)
- Irinotecan Impurity 27 (CAS 802277-44-7)
- Tert-butyl 3-amino-4-(2-ethoxy-5-fluorophenyl)piperidine-1-carboxylate (CAS 1354960-24-9)
- 3-Bromo-4-((4-bromobenzyl)oxy)-5-methoxybenzoic acid (CAS 1153461-81-4)
- 2-[4-(dimethylsulfamoyl)phenyl]propanoic acid (CAS 1304886-37-0)
- 1-(2-Fluorophenyl)-3-{1-[3-(pyrazin-2-yl)-1,2,4-oxadiazol-5-yl]cyclohexyl}urea (CAS 1396848-57-9)
- 2-Bromo-6-formylisonicotinonitrile (CAS 1289138-86-8)
- Heptapeptide-6 (CAS CATO-CPTD788823)
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