Nintedanib Impurity 147 CAS CATO-C4X-1814147

Description

Compared with other compounds in its class, the molecular weight of 320.00 g/mol gives Nintedanib Impurity 147 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

CATO supplies Nintedanib Impurity 147 (CAS CATO-C4X-1814147), a pharmacopoeial impurity reference standard (molecular formula C10H10Cl4O3, MW 320.00 g/mol) used for the identification and quantification of trace impurities in APIs.

Nintedanib Impurity 147 (C10H10Cl4O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

As a certified reference material (CRM), Nintedanib Impurity 147 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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