Nintedanib Impurity 89 CAS CATO-C4X-181489
| CAS No. | CATO-C4X-181489 |
| Molecular Formula | C16H15NO6 |
| Molecular Weight | 317.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Nintedanib Impurity 89 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Nintedanib Impurity 89 (CAS CATO-C4X-181489), a pharmacopoeial impurity reference standard (molecular formula C16H15NO6, MW 317.29 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Nintedanib Impurity 89 (C16H15NO6) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C16H15NO6 |
| Molecular Weight | 317.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Nintedanib Standards
- Nintedanib Impurity 122 (CAS CATO-C4X-1814122)
- Nintedanib Impurity 85 (CAS CATO-C4X-181485)
- Nintedanib Impurity 146 (CAS CATO-C4X-1814146)
- Nintedanib Impurity 147 (CAS CATO-C4X-1814147)
- Nintedanib Impurity 149 (CAS CATO-C4X-1814149)
- Nintedanib Impurity 129 (CAS CATO-C4X-1814129)
- Nintedanib Impurity 36 (CAS 1160293-27-5)
- Nintedanib Impurity 154 (CAS CATO-C4X-1814154)
Recommended Standards
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- Omadacycline Impurity 33 (CAS CATO-C4X-285733)
- Clomipramine EP Impurity D (CAS 3589-22-8)
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- (2,2-Dimethoxyethyl)(4-methoxyphenyl)sulfane (CAS 858816-12-3)
- N-(2-Bromophenyl)-2-(methylamino)acetamide (CAS 900641-73-8)
- 4-Phenoxy-3-fluorobenzaldehyde, 97% (CAS 887576-87-6)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com