Nintedanib Impurity 148 CAS CATO-C4X-1814148
| CAS No. | CATO-C4X-1814148 |
| Molecular Formula | C10H9Cl5O3 |
| Molecular Weight | 354.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Nintedanib Impurity 148.
Nintedanib Impurity 148 (CAS CATO-C4X-1814148) is a certified pharmaceutical impurity reference standard with the molecular formula C10H9Cl5O3 and a molecular weight of 354.44 g/mol.
Based on its molecular formula C10H9Cl5O3, Nintedanib Impurity 148 contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 354.44 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Nintedanib Impurity 148 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H9Cl5O3 |
| Molecular Weight | 354.44 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Nintedanib Standards
- Nintedanib Impurity 13 (CAS 1253769-13-9)
- Nintedanib Impurity 49 (CAS 1168152-07-5)
- Nintedanib Impurity 128 (CAS CATO-C4X-1814128)
- Nintedanib Impurity 119 (CAS CATO-C4X-1814119)
- Nintedanib Impurity 162 (CAS CATO-C4X-1814162)
- Nintedanib Impurity 134 (CAS CATO-C4X-1814134)
- Nintedanib Impurity 26 (CAS CATO-C4X-181426)
- Nintedanib Impurity 51 (Z-Isomer) (CAS 2102162-79-6)
Recommended Standards
- Vincamine (CAS 1617-90-9)
- Peramivir Impurity 113 (CAS CATO-C4X-1833113)
- Norethisterone Acetate EP Impurity G (CAS 438244-27-0)
- Peramivir Impurity 114 (CAS CATO-C4X-1833114)
- Pramipexole Impurity 60 (CAS 687639-03-8)
- Faropenem Impurity 40 (CAS CATO-C4X-128940)
- Aprepitant Impurity 36 (CAS 638990-20-2)
- (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(naphthalen-2-yl)butanoic acid (CAS 1260587-11-8)
- 6-Fluorospiro[chromane-2,1'-cyclopentan]-4-one (CAS 111478-02-5)
- 2-(5-Methylthiophen-2-yl)-2-oxoacetaldehyde (CAS 1430823-64-5)
- Benzyl-PEG3-CH2-Boc (CAS 1443467-88-6)
- 3-Bromo-6-chloro-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one (CAS 502173-64-0)
- 4-(4-Acetamidophenylsulfonamido)phenylacetic Acid (CAS 82101-23-3)
- Semaglutide impurity 270 (CAS CATO-C4X-2226270)
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