Paclitaxel Impurity 18 CAS CATO-C4X-184218
| CAS No. | CATO-C4X-184218 |
| Molecular Formula | C45H53NO14 |
| Molecular Weight | 831.90 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 831.90 g/mol gives Paclitaxel Impurity 18 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Paclitaxel Impurity 18 (CAS CATO-C4X-184218) is a certified pharmaceutical impurity reference standard with the molecular formula C45H53NO14 and a molecular weight of 831.90 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, Paclitaxel Impurity 18 is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 831.90 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C45H53NO14 |
| Molecular Weight | 831.90 g/mol |
| Purity | >90% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 20.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Paclitaxel Standards
- Paclitaxel EP Impurity A (CAS 173101-54-7)
- Paclitaxel EP Impurity B (CAS 71610-00-9)
- Paclitaxel EP Impurity D (CAS 150547-36-7)
- Paclitaxel EP Impurity R (CAS 158948-96-0)
- Paclitaxel Impurity R (CAS 159001-25-9)
- Paclitaxel Impurity 38 (CAS 173101-55-8)
- Paclitaxel Impurity 58 (CAS CATO-C4X-184258)
- Paclitaxel Impurity 61 (CAS CATO-C4X-184261)
Recommended Standards
- Abz-Phe-Arg-Lys(Dnp)-Pro-OH (CAS 500799-61-1)
- N-[(11bR)-2,6-Di-9-anthracenyl-4-oxidodinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl]-1,1,1-trifluoromethanesulfonamide (CAS 957790-95-3)
- Larotaxel (CAS 156294-36-9)
- 1,1,1-Trifluoro-N-[(11bS)-8,9,10,11,12,13,14,15-octahydro-4-oxido-2,6-di-9-phenanthrenyldinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl]methanesulfonamide (CAS 2757287-60-6)
- Axitinib Impurity 14 (CAS CATO-C4X-107114)
- Ticagrelor Impurity 62 (CAS CATO-C4X-109362)
- Olsalazine EP Impurity B (CAS 752188-68-4)
- 5-Amino-2-chloro-N-(2-(difluoromethoxy)phenyl)benzamide (CAS 1094218-45-7)
- Everolimus Impurity 25 (CAS CATO-C4X-112225)
- 4-Amino-6-(2-thienyl)-1,6-dihydro-1,3,5-triazine-2-thiol (CAS 1142208-12-5)
- Rel-(3R,4R)-1,2,3,4-Tetrahydro-1-oxo-3-(3-pyridinyl)-2-(2,2,2-trifluoroethyl)-4-isoquinolinecarboxylic acid (CAS 1424799-69-8)
- 5-methanesulfonyl-1,2-dihydropyridin-2-one (CAS 18085-51-3)
- 3-Methyladipoyl Chloride (CAS 44987-62-4)
- Semaglutide Impurity 138 (CAS CATO-C4X-2226138)
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