Tolvaptan Impurity 64 CAS CATO-C4X-195564
| CAS No. | CATO-C4X-195564 |
| Molecular Formula | C18H15BrN2O4 |
| Molecular Weight | 403.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Tolvaptan Impurity 64 (CAS CATO-C4X-195564) is a certified pharmaceutical impurity reference standard with the molecular formula C18H15BrN2O4 and a molecular weight of 403.23 g/mol.
Tolvaptan Impurity 64 (C18H15BrN2O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Tolvaptan Impurity 64 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H15BrN2O4 |
| Molecular Weight | 403.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Tolvaptan Standards
- Tolvaptan Impurity 76 (CAS 2458812-63-8)
- Tolvaptan Impurity 22 (CAS CATO-C4X-195522)
- Tolvaptan Impurity 129 (CAS 1448365-49-8)
- Tolvaptan Impurity 6 (CAS 137976-61-5)
- Tolvaptan Impurity 72 (CAS CATO-C4X-195572)
- Tolvaptan Impurity 118 (CAS CATO-C4X-1955118)
- Tolvaptan Impurity 124 (CAS CATO-C4X-1955124)
- Tolvaptan Impurity 89 (CAS 137977-65-2)
Recommended Standards
- Topilutamide (CAS 260980-89-0)
- (E)-2-nitro-2-(phenylsulfonyl)acetaldehyde O-(2,6-dichlorobenzyl) oxime (CAS 338397-57-2)
- Ethyl 1-benzyl-6-bromo-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate (CAS 1190198-34-5)
- 7-(4-Nitrophenoxy)-2,4-bis(trifluoromethyl)-1,8-naphthyridine (CAS 338978-20-4)
- Brivaracetam impurity 99 (CAS 1262340-23-7)
- Gimeracil impurity 12 (CAS 149143-68-0)
- Cefotaxime EP Impurity F (CAS 175032-97-0)
- 7-Bromo-4,8-dimethylquinolin-2-ol (CAS 1367706-85-1)
- 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)cycloheptanone (CAS 350498-94-1)
- Biotin Impurity 37 (CAS CATO-C4X-156337)
- 2-(Furan-2-yl)-5-nitrobenzofuran (CAS 89266-64-8)
- tert-Butyl (2-acetyl-5-bromophenyl)carbamate (CAS 1824285-78-0)
- 2-((4-Methoxybenzyl)thio)-3-methylquinazolin-4(3H)-one (CAS 90852-47-4)
- Tau Peptide (274-288) trifluoroacetate salt (CAS 330456-39-8)
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