Nebivolol Impurity 75 CAS CATO-C4X-196875
| CAS No. | CATO-C4X-196875 |
| Molecular Formula | C14H17FO3S |
| Molecular Weight | 284.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Nebivolol Impurity 75 (CAS CATO-C4X-196875), a pharmacopoeial impurity reference standard (molecular formula C14H17FO3S, MW 284.35 g/mol) used for the identification and quantification of trace impurities in APIs.
Nebivolol Impurity 75 (C14H17FO3S) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H17FO3S |
| Molecular Weight | 284.35 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Nebivolol Standards
- Nebivolol Impurity 67 (CAS CATO-C4X-196867)
- Nebivolol Impurity 70 (CAS CATO-C4X-196870)
- Nebivolol Impurity 54 (CAS CATO-C4X-196854)
- Nebivolol Impurity 55 (CAS CATO-C4X-196855)
- Nebivolol Impurity 14 (CAS 129050-29-9)
- Nebivolol Impurity 15 (CAS 1029684-20-5)
- Nebivolol Impurity 64 (CAS CATO-C4X-196864)
- Nebivolol Impurity 65 (CAS CATO-C4X-196865)
Recommended Standards
- Artemisinin Impurity 11 (CAS 81496-81-3)
- Tropicamide (CAS 1508-75-4)
- Pranlukast Impurity 11 (CAS 136450-05-0)
- Nefopam impurity 16 (CAS CATO-C4X-283716)
- Azithromycin Impurity 36 (CAS 57794-18-0)
- Ertapenem Impurity 64 (CAS CATO-C4X-163364)
- Azilsartan Impurity 94 (CAS 2839197-75-8)
- Ropinirole-d7 Hydrochloride (CAS 1261396-31-9)
- Metaraminol Impurity 15 (CAS 13103-80-5)
- 2-Methoxy-1,3-benzoxazol-5-amine (CAS 1313868-77-7)
- N-(2,4-Dimethoxybenzyl)-5-fluorothiazol-2-amine (CAS 2007920-92-3)
- 2-Ethynyl-1,3-difluoro-5-methoxybenzene (CAS 1857323-46-6)
- 1-(Difluoromethyl)-1H-pyrazole-4-carbonitrile (CAS 1229623-41-9)
- Semaglutide impurity 289 (CAS CATO-C4X-2226289)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com